INJECTION

INJECTION

LEVERAGING THE PATIENT JOURNEY TO OPTIMISE DEVICE USE AT HOME

Séverine Duband and Mark Tunkel discuss the importance of device optimisation to increase patient safety during self-administration of medication.

PREFILLED SYRINGES

FINDING THE RIGHT PACKAGING FOR BIOLOGIC DRUGS

Christian Helbig introduces a new 2.25 mL version of SCHOTT’s syriQ BioPure® prefillable syringes designed specifically for the biologics market and, developed in partnership with WL Gore, the world’s first silicone-free glass syringe system.

COVID-19 NEWS

Lexaria Bioscience

Lexaria Bioscience Expands Pharma Division for development of Lipophilic Antivirals against COVID-19

Lexaria is to investigate how its patented DehydraTECH drug delivery technology could enhance delivery and effectiveness of certain antiviral drugs in the fight against coronavirus disease COVID-19.  Lexaria intends to expand collaboration with leading laboratories as soon as possible.

PREFILLED SYRINGES

Gene Rhode Fuensalida Pantig

SHL Group

ADDRESSING COMPLEX BIOLOGICS WITH RATIONAL DRUG DEVICE DESIGN

Gene Rhode Fuensalida Pantig reviews drug development over the years, the discovery of biologics as therapeutic agents and the emergence of autoinjectors, in correspondence with Hans Lin, PhD, a Research Fellow from Academia Sinica, Taiwan.

PREFILLED SYRINGES

Joe Reynolds

Noble

ENHANCING THE PATIENT EXPERIENCE FOR SELF-INJECTION SYSTEMS

The complexity of injectable treatment regimens for chronic diseases means onboarding aids can be integral to disease management. Joe Reynolds discusses the role of demonstration devices in improving the patient experience and adherence.

WEARABLES

Jennifer King

Enable Injections

DRUG DELIVERY DESIGNED TO IMPROVE THE PATIENT EXPERIENCE

Jennifer King looks at the delivery challenges of novel therapies for chronic diseases using a specific patient’s story as an example, going on to highlight the ways in which a novel device approach could make all the difference for patients.

INJECTION

Dr Andreas Schneider

Ypsomed

HOW USERS DISTINGUISH BETWEEN SELF-INJECTION DEVICE PLATFORM VARIANTS

Andreas Schneider highlights how the ever-increasing interest in device platforms raises concerns around the broad availability of lookalike autoinjectors that may result in inappropriate medication usage. He summarises a recent empirical study¹ providing insights into which device attributes drive device distinguishability.

PREFILLED SYRINGES

Shota Arakawa

Mitsubishi Gas Chemical

OXYCAPT MULTILAYER PLASTIC VIAL AND SYRINGE

Shota Arakawa and Tomohiro Suzuki, discuss the benefits of the OXYCAPT™ multilayer plastic vial and syringe for the rapidly growing field of biologics and regenerative medicines.

EXPERT VIEW

Jos van Noort

CHOOSING THE RIGHT LABEL MATERIAL FOR PREFILLED SYRINGES

Jos van Noort outlines some of the key factors that must be taken into consideration when selecting a label for prefillable syringes.

WEARABLES

Thomas Mayer

Sonceboz

NEXT-GENERATION WEARABLE DELIVERY DEVICES FOR LARGE-VOLUME BIOLOGICS

Thomas Mayer discusses Sonceboz’s platform of wearable injection devices for large-volume biologics, which can follow drugs from clinical trials to commercial phase through lifecycle management, which reduces risk and speeds time to market.

EXPERT VIEW

Elizma Parry

EU MDR: ANCILLARY DELIVERY DEVICES FACE EQUAL SCRUTINY TO STANDALONE MEDICAL DEVICES

Elizma Parry offers her expertise and practical guidance to businesses hoping to achieve a CE mark for a medical device, with new EU regulations being implemented this year.

PREFILLED SYRINGES

Wolfgang Moersch

ZwickRoell

PRODUCT SHOWCASE: ZwickRoell Parenteral Device Testing Platform

ZwickRoell offers a wide variety of standardised test fixtures for parenteral devices including, described here: testing prefilled syringes to ISO 11040-4, -6 & -8; testing of Luer/Luer lock connections; serial, parallel and fully automatic syringe testing; and traceable, tamper-proof test results.

INJECTION

Tom Oakley

Springboard

DEVELOPMENT OF A NEW HIGH-PERFORMANCE AUTOINJECTOR

Tom Oakley and Sigrid Saaler-Reinhardt discuss the development of the Midas Pharma’s NIS cartridge-based autoinjector.

EXPERT VIEW

George I’ons

PREFILLED SAFETY SYRINGE MARKET THRIVES AMID SELF-ADMINISTRATION TREND

George I’ons looks at how the growing trend of patient self-administration is driving demand for prefilled safety syringes.

EXPERT VIEW

Dr Paolo Fiorini

LARGE-VOLUME INJECTORS: RISE IN BIOLOGICS BRINGS CHALLENGES

Developing devices capable of delivering highly viscous biologic drug formulations at high volumes does not come without its challenges. Paolo Fiorini, Gerard Linnane, Michael Kiely, Maciej Grygorczuk and Joshua Coyne discuss these challenges and the merits of various drive solutions.

WEARABLES

Dr Temitope Sodunke

BD (Becton Dickinson & Company)

ADDRESSING THE EVOLVING NEEDS OF VARIABLE DRUG DELIVERY REGIMENS

Temitope Sodunke introduces the BD Evolve™ On-body Injector and describes how the device is designed specifically to address the rapidly evolving needs of the pharma industry and meet patient requirements.

EXPERT VIEW

Stephen Augustyn

HOW TO DESIGN A BODY-WORN INJECTOR

Body-worn injectors require you to understand your user, your drug and your technology – and there are numerous pitfalls for the unwary. Stephen Augustyn shares some insights.

INJECTION

Marino Kriheli

Equashield

THE NEED FOR CSTDS IN BOTH MANUAL AND AUTOMATED COMPOUNDING

Marino Kriheli discusses the benefits of using closed system transfer devices (CSTDs) in both manual and automated hazardous drugs compounding.

INJECTION

David Fink

Ximedica

THE CHALLENGES OF A CHANGING MARKET & THE BENEFITS OF DEVELOPMENT FLEXIBILITY

David Fink and Sheila Trgovac describe how adopting a flexible development model in mid-to-late development brings benefits through to commercialisation, especially in the context of a changing market.

VIDEO

John Merhige

Credence MedSystems

VIDEO: Credence Connect from Credence MedSystems

Credence MedSystems takes us through the use steps of its new Credence Connect™ autosensing injection system, and smartphone app.

CONNECTIVITY

Rachel An

Quantex Arc

HOW TO DEVELOP A CUSTOMISED IOT PLATFORM WITH A RUNNING START

Do you need a drug delivery Internet of Things (IoT) platform across your entire portfolio of drugs that is agnostic to the type of source container, drug viscosity and the volume to be dispensed? Rachel An and Gillian Harding-Moore discuss how to develop such a platform with a running start.

CONNECTIVITY

Neil Williams

Phillips-Medisize

NEXT-GENERATION CONNECTED DRUG DELIVERY SUPPORTS DATA LIQUIDITY & COST SAVINGS

Neil Williams discusses medication non-adherence, the toll it takes on the healthcare system and how integration, analytics and more affordable connectivity in drug delivery devices as part of a connected health ecosystem improves patient care and lowers costs.

CONNECTIVITY

Barbara Taylor

Portal Instruments

AN INJECTION OF CONNECTED NEEDLE-FREE INNOVATION

Barb Taylor discusses the next generation of needle-free injection devices, which incorporate connectivity.

EXPERT VIEW

Dr Juan Nogueira

CHOOSING THE RIGHT CONNECTIVITY FOR DRUG DELIVERY AND MEDICAL PRODUCTS

Juan Nogueira; Tommaso Borghi and Marco Vergani discuss the factors that need to be taken into account in the selection of connectivity technology for a drug delivery device or other medical product.

CONNECTIVITY

Biocorp

PRODUCT SHOWCASE: Injay – Connected Prefilled Syringe

Biocorp presents Injay, the first prefilled syringe with built-in connectivity, providing a cost-effective and easy-to-implement solution that improves treatment adherence, upholds quality of reporting, and provides a secure treatment protocol and traceability.

INJECTION

Orfeo Niedermann

Ypsomed

SUCCESS FACTORS FOR THE YPSOMATE FAMILY OF AUTOINJECTORS

Orfeo Niedermann looks at the key factors behind the growth and continued success of the YpsoMate family of two-step autoinjectors. He also introduces YpsoMate Design, which enables freeform outer shell design around the proven YpsoMate mechanism and manufacturing lines.

EXPERT VIEW

Dr Jeffrey Philippson

THE INTERFACE BETWEEN PREFILLED SYRINGE AND AUTOINJECTOR – A DEVELOPMENT FRAMEWORK

Jeffrey Philippson and Tom Kemp outline the challenges for autoinjector developers at the interface between the device and the prefilled syringe – and describe a framework to formalise analysis of the interface.

INJECTION

Tibor Hlobik

West Pharmaceutical Services

SIMPLIFYING THE PROCESS OF DEVELOPING PREFILLED SYRINGES

Tibor Hlobik describes how the use of cyclic olefin polymer delivery systems is gaining in popularity because of the benefits they have over glass systems for complex drug applications, and explains what this advance in technology can offer drug manufacturers.

INJECTION

Michael McGowan

SHL Group

30 YEARS IN THE MAKING – AN INSIDE PERSPECTIVE ON THE EMERGENCE OF AUTOINJECTORS

Michael McGowan, Director of Market Intelligence at SHL Group, gives a perspective on the emergence of the autoinjector as a key component of the drug delivery industry, in the context of SHL celebrating its 30th anniversary this year – a journey of rapid development that reflects the growing demand for advanced drug delivery systems in the healthcare market. 

INJECTION

Dr Fred Metzmann

Haselmeier

DEVELOPMENTS IN SELF-INJECTION DEVICES FOR COMBINATION PRODUCTS

Fred Metzmann reports on the latest state-of-the-art developments in innovative injection devices for combination products in subcutaneous self-application. He outlines Haselmeier's product platform strategy for single-use (D-Flex) and re-usable (i-pen²) injection-pen systems, and related services and looks at the company’s connected digital solutions.

PREFILLED SYRINGES

Roland Lindner

sortimat

LED-GENERATED UV FOR ADHESIVE CURING IN MEDICAL DEVICES

Roland Lindner, Matthias Schulze and Bill Jaworski discuss how the needs around adhesive use in the manufacture of medical devices such as glass syringes have evolved and how ATS sortimat has developed a new process to meet industry demands.

INDUSTRIALISATION

Simon Strothers

3P Innovation

F2V: A STERILE, CUSTOMISABLE LIQUID FILL-FINISH PLATFORM FOR THE TOTAL LIFECYCLE

Simon Strothers presents an integrated fill-finish platform, F2V, designed to represent a commercial filling system as a bench-top solution. The article also includes a recent case study where the F2V was used by Consort Medical to help develop and industrialise a flagship delivery device. 

EXPERT VIEW

Napoleon Monroe

PATIENTS, MANUFACTURERS & PRACTITIONERS CAN LEAD ADOPTION OF CONNECTED COMBINATION PRODUCTS

Napoleon Monroe asks why connectivity has failed to advance rapidly, and argues that many stakeholders can benefit if the adoption of connectivity for drug delivery can be accelerated. While this article will centre on pharmaceutical combination products, the essential points also relate more broadly to pharmaceuticals and medical devices.

INJECTION

David Fink

Ximedica

ASSESSING USABILITY EARLY FOR OPTIMAL INJECTION PEN DESIGN

David Fink and Stefan Gaul use the example of Haselmeier’s D-Flex system to explain why it is important to undertake a full use-related risk analysis for injection pen products to assess their usability and identify any risks, highlighting the importance of considering usability right from the start.

PREFILLED SYRINGES

Tomohiro Suzuki

Mitsubishi Gas Chemical

LATEST UPDATE ON OXYCAPT™ MULTILAYER PLASTIC VIAL AND SYRINGE

Tomohiro Suzuki gives an update on the development of the OXYCAPT™ multilayer plastic vial and syringe – highlighting the results of recent tests comparing it with existing glass syringes.

INDUSTRIALISATION

Berthold Schopferer

Zahoransky

Z.BLIZZARD AUTOMATION SYSTEM FOR PFS: IMPROVING THE LIVES OF PATIENTS

With the ultimate objective of improving patients’ lives, Berthold Schopferer provides an overview of the company’s customer-specific automated manufacturing and assembly equipment offering for prefillable polymer syringes.

INDUSTRIALISATION

Wolfgang Moersch

ZwickRoell

PRODUCT SHOWCASE: ZwickRoell Parenteral Device Testing Platform

ZwickRoell provides an overview of its parenteral device testing platform including roboTest, and associated software testXpert III and autoEdition3.

INJECTION

Marta Vilaplana

Oval Medical Technologies

FUNCTION-BASED PRIMARY PACKAGING DESIGN FOR INJECTING VISCOUS NON-NEWTONIAN FORMULATIONS

Marta Vilaplana; Alex Vasiev and Susie White explore the challenges of delivering high-viscosity, non-Newtonian fluids emphasising the importance of robust tools to characterise specific device and formulation parameters in light of increasing regulatory scrutiny.