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INJECTION
INJECTION
LEVERAGING THE PATIENT JOURNEY TO OPTIMISE DEVICE USE AT HOME
Séverine Duband and Mark Tunkel discuss the importance of device optimisation to increase patient safety during self-administration of medication.
PREFILLED SYRINGES
FINDING THE RIGHT PACKAGING FOR BIOLOGIC DRUGS
Christian Helbig introduces a new 2.25 mL version of SCHOTT’s syriQ BioPure® prefillable syringes designed specifically for the biologics market and, developed in partnership with WL Gore, the world’s first silicone-free glass syringe system.
COVID-19 NEWS
Lexaria Bioscience
Lexaria Bioscience Expands Pharma Division for development of Lipophilic Antivirals against COVID-19
Lexaria is to investigate how its patented DehydraTECH drug delivery technology could enhance delivery and effectiveness of certain antiviral drugs in the fight against coronavirus disease COVID-19. Lexaria intends to expand collaboration with leading laboratories as soon as possible.
PREFILLED SYRINGES
Gene Rhode Fuensalida Pantig
SHL Group
ADDRESSING COMPLEX BIOLOGICS WITH RATIONAL DRUG DEVICE DESIGN
Gene Rhode Fuensalida Pantig reviews drug development over the years, the discovery of biologics as therapeutic agents and the emergence of autoinjectors, in correspondence with Hans Lin, PhD, a Research Fellow from Academia Sinica, Taiwan.
PREFILLED SYRINGES
Joe Reynolds
Noble
ENHANCING THE PATIENT EXPERIENCE FOR SELF-INJECTION SYSTEMS
The complexity of injectable treatment regimens for chronic diseases means onboarding aids can be integral to disease management. Joe Reynolds discusses the role of demonstration devices in improving the patient experience and adherence.
WEARABLES
Jennifer King
Enable Injections
DRUG DELIVERY DESIGNED TO IMPROVE THE PATIENT EXPERIENCE
Jennifer King looks at the delivery challenges of novel therapies for chronic diseases using a specific patient’s story as an example, going on to highlight the ways in which a novel device approach could make all the difference for patients.
INJECTION
Dr Andreas Schneider
Ypsomed
HOW USERS DISTINGUISH BETWEEN SELF-INJECTION DEVICE PLATFORM VARIANTS
Andreas Schneider highlights how the ever-increasing interest in device platforms raises concerns around the broad availability of lookalike autoinjectors that may result in inappropriate medication usage. He summarises a recent empirical study
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providing insights into which device attributes drive device distinguishability.
PREFILLED SYRINGES
Shota Arakawa
Mitsubishi Gas Chemical
OXYCAPT MULTILAYER PLASTIC VIAL AND SYRINGE
Shota Arakawa and Tomohiro Suzuki, discuss the benefits of the OXYCAPT™ multilayer plastic vial and syringe for the rapidly growing field of biologics and regenerative medicines.
EXPERT VIEW
Jos van Noort
CHOOSING THE RIGHT LABEL MATERIAL FOR PREFILLED SYRINGES
Jos van Noort outlines some of the key factors that must be taken into consideration when selecting a label for prefillable syringes.
WEARABLES
Thomas Mayer
Sonceboz
NEXT-GENERATION WEARABLE DELIVERY DEVICES FOR LARGE-VOLUME BIOLOGICS
Thomas Mayer discusses Sonceboz’s platform of wearable injection devices for large-volume biologics, which can follow drugs from clinical trials to commercial phase through lifecycle management, which reduces risk and speeds time to market.
EXPERT VIEW
Elizma Parry
EU MDR: ANCILLARY DELIVERY DEVICES FACE EQUAL SCRUTINY TO STANDALONE MEDICAL DEVICES
Elizma Parry offers her expertise and practical guidance to businesses hoping to achieve a CE mark for a medical device, with new EU regulations being implemented this year.
PREFILLED SYRINGES
Wolfgang Moersch
ZwickRoell
PRODUCT SHOWCASE: ZwickRoell Parenteral Device Testing Platform
ZwickRoell offers a wide variety of standardised test fixtures for parenteral devices including, described here: testing prefilled syringes to ISO 11040-4, -6 & -8; testing of Luer/Luer lock connections; serial, parallel and fully automatic syringe testing; and traceable, tamper-proof test results.
INJECTION
Tom Oakley
Springboard
DEVELOPMENT OF A NEW HIGH-PERFORMANCE AUTOINJECTOR
Tom Oakley and Sigrid Saaler-Reinhardt discuss the development of the Midas Pharma’s NIS cartridge-based autoinjector.
EXPERT VIEW
George I’ons
PREFILLED SAFETY SYRINGE MARKET THRIVES AMID SELF-ADMINISTRATION TREND
George I’ons looks at how the growing trend of patient self-administration is driving demand for prefilled safety syringes.
EXPERT VIEW
Dr Paolo Fiorini
LARGE-VOLUME INJECTORS: RISE IN BIOLOGICS BRINGS CHALLENGES
Developing devices capable of delivering highly viscous biologic drug formulations at high volumes does not come without its challenges. Paolo Fiorini, Gerard Linnane, Michael Kiely, Maciej Grygorczuk and Joshua Coyne discuss these challenges and the merits of various drive solutions.
WEARABLES
Dr Temitope Sodunke
BD (Becton Dickinson & Company)
ADDRESSING THE EVOLVING NEEDS OF VARIABLE DRUG DELIVERY REGIMENS
Temitope Sodunke introduces the BD Evolve™ On-body Injector and describes how the device is designed specifically to address the rapidly evolving needs of the pharma industry and meet patient requirements.
EXPERT VIEW
Stephen Augustyn
HOW TO DESIGN A BODY-WORN INJECTOR
Body-worn injectors require you to understand your user, your drug and your technology – and there are numerous pitfalls for the unwary. Stephen Augustyn shares some insights.
INJECTION
Marino Kriheli
Equashield
THE NEED FOR CSTDS IN BOTH MANUAL AND AUTOMATED COMPOUNDING
Marino Kriheli discusses the benefits of using closed system transfer devices (CSTDs) in both manual and automated hazardous drugs compounding.
INJECTION
David Fink
Ximedica
THE CHALLENGES OF A CHANGING MARKET & THE BENEFITS OF DEVELOPMENT FLEXIBILITY
David Fink and Sheila Trgovac describe how adopting a flexible development model in mid-to-late development brings benefits through to commercialisation, especially in the context of a changing market.
VIDEO
John Merhige
Credence MedSystems
VIDEO: Credence Connect from Credence MedSystems
Credence MedSystems takes us through the use steps of its new Credence Connect™ autosensing injection system, and smartphone app.
CONNECTIVITY
Rachel An
Quantex Arc
HOW TO DEVELOP A CUSTOMISED IOT PLATFORM WITH A RUNNING START
Do you need a drug delivery Internet of Things (IoT) platform across your entire portfolio of drugs that is agnostic to the type of source container, drug viscosity and the volume to be dispensed? Rachel An and Gillian Harding-Moore discuss how to develop such a platform with a running start.
CONNECTIVITY
Neil Williams
Phillips-Medisize
NEXT-GENERATION CONNECTED DRUG DELIVERY SUPPORTS DATA LIQUIDITY & COST SAVINGS
Neil Williams discusses medication non-adherence, the toll it takes on the healthcare system and how integration, analytics and more affordable connectivity in drug delivery devices as part of a connected health ecosystem improves patient care and lowers costs.
CONNECTIVITY
Barbara Taylor
Portal Instruments
AN INJECTION OF CONNECTED NEEDLE-FREE INNOVATION
Barb Taylor discusses the next generation of needle-free injection devices, which incorporate connectivity.
EXPERT VIEW
Dr Juan Nogueira
CHOOSING THE RIGHT CONNECTIVITY FOR DRUG DELIVERY AND MEDICAL PRODUCTS
Juan Nogueira; Tommaso Borghi and Marco Vergani discuss the factors that need to be taken into account in the selection of connectivity technology for a drug delivery device or other medical product.
CONNECTIVITY
Biocorp
PRODUCT SHOWCASE: Injay – Connected Prefilled Syringe
Biocorp presents Injay, the first prefilled syringe with built-in connectivity, providing a cost-effective and easy-to-implement solution that improves treatment adherence, upholds quality of reporting, and provides a secure treatment protocol and traceability.
INJECTION
Orfeo Niedermann
Ypsomed
SUCCESS FACTORS FOR THE YPSOMATE FAMILY OF AUTOINJECTORS
Orfeo Niedermann looks at the key factors behind the growth and continued success of the YpsoMate family of two-step autoinjectors. He also introduces YpsoMate Design, which enables freeform outer shell design around the proven YpsoMate mechanism and manufacturing lines.
EXPERT VIEW
Dr Jeffrey Philippson
THE INTERFACE BETWEEN PREFILLED SYRINGE AND AUTOINJECTOR – A DEVELOPMENT FRAMEWORK
Jeffrey Philippson and Tom Kemp outline the challenges for autoinjector developers at the interface between the device and the prefilled syringe – and describe a framework to formalise analysis of the interface.
INJECTION
Tibor Hlobik
West Pharmaceutical Services
SIMPLIFYING THE PROCESS OF DEVELOPING PREFILLED SYRINGES
Tibor Hlobik describes how the use of cyclic olefin polymer delivery systems is gaining in popularity because of the benefits they have over glass systems for complex drug applications, and explains what this advance in technology can offer drug manufacturers.
INJECTION
Michael McGowan
SHL Group
30 YEARS IN THE MAKING – AN INSIDE PERSPECTIVE ON THE EMERGENCE OF AUTOINJECTORS
Michael McGowan, Director of Market Intelligence at SHL Group, gives a perspective on the emergence of the autoinjector as a key component of the drug delivery industry, in the context of SHL celebrating its 30th anniversary this year – a journey of rapid development that reflects the growing demand for advanced drug delivery systems in the healthcare market.
INJECTION
Dr Fred Metzmann
Haselmeier
DEVELOPMENTS IN SELF-INJECTION DEVICES FOR COMBINATION PRODUCTS
Fred Metzmann reports on the latest state-of-the-art developments in innovative injection devices for combination products in subcutaneous self-application. He outlines Haselmeier's product platform strategy for single-use (D-Flex) and re-usable (i-pen²) injection-pen systems, and related services and looks at the company’s connected digital solutions.
PREFILLED SYRINGES
Roland Lindner
sortimat
LED-GENERATED UV FOR ADHESIVE CURING IN MEDICAL DEVICES
Roland Lindner, Matthias Schulze and Bill Jaworski discuss how the needs around adhesive use in the manufacture of medical devices such as glass syringes have evolved and how ATS sortimat has developed a new process to meet industry demands.
INDUSTRIALISATION
Simon Strothers
3P Innovation
F2V: A STERILE, CUSTOMISABLE LIQUID FILL-FINISH PLATFORM FOR THE TOTAL LIFECYCLE
Simon Strothers presents an integrated fill-finish platform, F2V, designed to represent a commercial filling system as a bench-top solution. The article also includes a recent case study where the F2V was used by Consort Medical to help develop and industrialise a flagship delivery device.
EXPERT VIEW
Napoleon Monroe
PATIENTS, MANUFACTURERS & PRACTITIONERS CAN LEAD ADOPTION OF CONNECTED COMBINATION PRODUCTS
Napoleon Monroe asks why connectivity has failed to advance rapidly, and argues that many stakeholders can benefit if the adoption of connectivity for drug delivery can be accelerated. While this article will centre on pharmaceutical combination products, the essential points also relate more broadly to pharmaceuticals and medical devices.
INJECTION
David Fink
Ximedica
ASSESSING USABILITY EARLY FOR OPTIMAL INJECTION PEN DESIGN
David Fink and Stefan Gaul use the example of Haselmeier’s D-Flex system to explain why it is important to undertake a full use-related risk analysis for injection pen products to assess their usability and identify any risks, highlighting the importance of considering usability right from the start.
PREFILLED SYRINGES
Tomohiro Suzuki
Mitsubishi Gas Chemical
LATEST UPDATE ON OXYCAPT™ MULTILAYER PLASTIC VIAL AND SYRINGE
Tomohiro Suzuki gives an update on the development of the OXYCAPT™ multilayer plastic vial and syringe – highlighting the results of recent tests comparing it with existing glass syringes.
INDUSTRIALISATION
Berthold Schopferer
Zahoransky
Z.BLIZZARD AUTOMATION SYSTEM FOR PFS: IMPROVING THE LIVES OF PATIENTS
With the ultimate objective of improving patients’ lives, Berthold Schopferer provides an overview of the company’s customer-specific automated manufacturing and assembly equipment offering for prefillable polymer syringes.
INDUSTRIALISATION
Wolfgang Moersch
ZwickRoell
PRODUCT SHOWCASE: ZwickRoell Parenteral Device Testing Platform
ZwickRoell provides an overview of its parenteral device testing platform including roboTest, and associated software testXpert III and autoEdition3.
INJECTION
Marta Vilaplana
Oval Medical Technologies
FUNCTION-BASED PRIMARY PACKAGING DESIGN FOR INJECTING VISCOUS NON-NEWTONIAN FORMULATIONS
Marta Vilaplana; Alex Vasiev and Susie White explore the challenges of delivering high-viscosity, non-Newtonian fluids emphasising the importance of robust tools to characterise specific device and formulation parameters in light of increasing regulatory scrutiny.
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