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GI/ORAL
CONNECTIVITY
THE TRUSTED TABLET: A NEW LEVEL OF SUPPLY CHAIN SECURITY FROM MASS DIGITALISATION OF MEDICINES
Kelly Boyer, Trent Lund and Barry McDough describe a means of mass digitalising medicines to address the problem of illegal and unauthorised production of pharmaceutical products in a meaningful way.
EARLY INSIGHT
PERSONALISING DRUG PRODUCTS USING 3D PRINTING
Sarah Trenfield and Abdul Basit look at the potential applications of 3D-printing technology to create personalised drug therapies in fields such as multiple drug therapy and paediatric/geriatric care and introduce FabRx’s 3D-printing system, which can produce formulations to suit a variety of situations.
COVID-19 NEWS
Lexaria Bioscience
Lexaria Bioscience Expands Pharma Division for development of Lipophilic Antivirals against COVID-19
Lexaria is to investigate how its patented DehydraTECH drug delivery technology could enhance delivery and effectiveness of certain antiviral drugs in the fight against coronavirus disease COVID-19. Lexaria intends to expand collaboration with leading laboratories as soon as possible.
EXPERT VIEW
Dr Ulrica Sehlstedt
TRANSFORMING HEALTHCARE – HOW CURATIVE THERAPIES WILL DISRUPT THE MARKET
Ulrica Sehlstedt, Craig Wylie, Thomas Unger, Rebecka Axelsson Wadman, Vikas Kharbanda, and Satoshi Ohara, all members of Arthur D. Little’s Healthcare and Life Sciences Practice, explain how the shift to curative treatments promises to transform the entire healthcare ecosystem.
RESPIRATORY
Dr Geoffroy Lumay
Granutools
HOW TO GAIN A FULL UNDERSTANDING OF POWDER FLOW PROPERTIES, AND THE BENEFITS OF DOING SO
Geoffroy Lumay, Naveen Mani Tripathi and Filip Francqui show how the association of three recently developed flow measurement techniques can be used to gain valuable insights into powder properties and characteristics.
EXPERT VIEW
Dr Aline Moulin
COMPACTION SIMULATION / INDUSTRIAL PRESS CORRELATION: TWO CASE STUDIES
Aline Moulin and Lucile Kowalski examine two case studies comparing compaction simulation with industrial compression.
EXPERT VIEW
Jamie Clayton
3D PRINTING DRUGS: LEARNING FROM THE PIONEERS
Jamie Clayton reviews the potential of 3D printing as a pharmaceutical production method and looks at the associated implications for formulation development, focusing on powder-based printing. He examines what leading experts now understand about how to specify powder feeds for 3D printing.
INDUSTRIALISATION
Jose Luis Encinas
Qualicaps
QUALI-V EXTRA DRY: A NOVEL CAPSULE FOR DELIVERING HYGROSCOPIC FORMULATIONS
Jose Luis Encinas and Susana Ecenarro explore how the use of Quali-V
®
Extra Dry capsules can help improve product stability and, crucially, lead to efficiencies and savings in drug product manufacture.
EXPERT VIEW
Dr Nidhi Prakash Sapkal
ORAL THIN FILMS: NOVEL TECHNOLOGY & ITS CHALLENGES
Presented from both the technology and formulation perspectives, Nidhi Prakash Sapkal and Anwar Siraj Daud discuss the challenges of industrialising oral thin films, a promising but difficult dosage form.
INDUSTRIALISATION
Hugues Benevent
Unither Pharmaceuticals
THE ODTECH PLATFORM: A RANGE OF READY-TO-USE ORAL FORMS
Hugues Benevent and Nathalie Masson introduce the ODtech™ platform technology for oral medications, designed to provide an easy-to-use and ready-to-industrialise solution for tackling the human factors issues of standard oral pills.
EXPERT VIEW
Jonathan Gaik
GO WITH THE FLOW – SOLVING POWDER FLOW CHALLENGES BEFORE PRODUCTION
Jonathan Gaik discusses the various problems in tablet compression that can be caused by not giving due care to powder flow in the development stage and how, by doing so, what would be serious problems at the industrial scale can be solved in advance.
EXPERT VIEW
Dr Damon C Smith
PREVENTION NOT CURE: AVOIDING A EUROPEAN PRESCRIPTION OPIOID EPIDEMIC
Damon Smith, Richard Dart and Christopher Hirst discuss the causes and possible solutions to the prescription opioid epidemic, as well as whether or not Europe is likely to face a similar fate.
GI/ORAL
Cécile Morin
Gattefossé
HIGH SHEAR COATING: A VERSATILE TASTE-MASKING PROCESS
Cécile Morin and Yvonne Rosiaux discuss taste-masking, covering the advantages of Precirol
®
ATO 5 and how Gattefossé’s high shear coating process presents an appealing alternative to standard fluid bed techniques.
EXPERT VIEW
Rob Davidson
ORAL FILMS – A MULTI-FACETED DRUG DELIVERY SYSTEM AND DOSAGE FORM
Oral films are a relative newcomer to the drug delivery space, though one with considerable potential. Rob Davidson and Jessica Rousset give an overview of this dosage form, from formulation through manufacturing to future outlook.
GI/ORAL
Dr Anna Malori
Bormioli Pharma
ORAL DRUG RECONSTITUTION: MAKING IT EASY AND ACCURATE VIA PACKAGING INNOVATION
Anna Malori discusses the oft overlooked challenges and difficulties of standard packaging systems for oral medications requiring reconstitution before use.
EXPERT VIEW
Rashmi Nair
THE SCIENCE OF SOLUBILITY AND THE SUCCESS OF AMORPHOUS SOLID DISPERSIONS
Rashmi Nair discusses the persistent challenge presented by poorly soluble drug formulations in oral drug delivery. Furthermore, she goes on to highlight the promise shown by amorphous solid dispersions, despite the difficulties they present.
GI/ORAL
Dr Michael Baumann
EXCIPIENT INNOVATION REQUIRES CLOSE COLLABORATION
Michael Baumann discusses the need for novel excipients in new drug development, the regulatory difficulties inherent to developing novel excipients and methods of innovation using current compendial excipients.
GI/ORAL
Dr Maria Montero Mirabet
Evonik
ADVANCED APPROACHES FOR DELAYED-RELEASE FORMULATIONS
Maria Montero Mirabet and Brigitte Skalsky, both of Evonik Health Care, review advances in delayed-release technology including advances in enteric-coating applications and the use of pulsatile technology to provide tailored lag times.
GI/ORAL
Don Barbieri
SPI Pharma
MEETING THE CHALLENGES OF PAEDIATRIC DOSING
Although paediatric drugs are traditionally administered in a liquid formulation, recent studies suggest that orally disintegrating mini-tablets may be a more accurate, convenient and less messy dosage form. Don Barbieri explores this method and reviews two case studies looking at whether quality standards can be met and the importance of taste in paediatric formulations.
EXPERT VIEW
Dr S Mohan Mohanraj
EVALUATING A NEW MICROSPHERE BASED CONTROLLED-RELEASE DELIVERY SYSTEM
S Mohan Mohanraj and Meir Kende discuss the development of a microsphere based delivery system for an orally administered anthrax vaccine.
GI/ORAL
Aia Malik
Lucideon
THE PRESCRIPTION ABUSE EPIDEMIC: DESIGNING A SOLUTION
Aia Malik and Gemma Budd discuss the journey behind Lucideon’s proprietary iCRTdeter technology which provides tamper-proofing and enhanced safety of pharmaceuticals. It has been used to give abuse-deterrent features to formulations of opioids and highly potent compounds.
GI/ORAL
Dr Carmen Popescu
Roquette
ORALLY DISINTEGRATING FILMS FOR THE DELIVERY OF BIOTHERAPEUTICS & NANO / MICROPARTICLE FORMULATIONS
Carmen Popescu summarises the benefits and applications of orally dissolving film dosage forms, with claims supported by two case studies, one demonstrating the suitability of ODFs for the delivery of micro and nanoparticles, the other showing how this property of ODFs exhibits promise as a next-generation immunisation system.
GI/ORAL
Dr Nathan Dormer
Orbis Biosciences
SINGLE-STEP FUNCTIONAL COATINGS FOR INCREASED EFFICIENCIES
In this article about oral drug innovation, Cory Berkland and Nathan Dormer focus on how enterics and reverse enterics are applied into dosage forms, and discuss the future of this class of drug formulation technology.
GI/ORAL
Dr Sejal R Ranmal
Intract Pharma
OPPORTUNITIES & INNOVATIONS IN COLONIC DRUG DELIVERY
Sejal R Ranmal, Vipul Yadav and Abdul W Basit describe recent insights into the physiology of the colon, advantages of targeting drug release to the colon and introduce Phloral®, Intract’s unique system for achieving drug release in the colon successfully and consistently.
EXPERT VIEW
Dr Nozer Mehta
TECHNOLOGIES & CLINICAL STUDIES FOR THE ORAL DELIVERY OF CALCITONIN
Nozer Mehta, James P Gilligan and William Stern summarise the different technologies that have been in development for oral delivery of peptides through the gastro-intestinal mucosal surfaces via the transcellular or the paracellular pathways and describe the results of several long-term clinical studies on the oral delivery of salmon calcitonin.
EXPERT VIEW
Stephen Tindal
SELECTING OPTIMAL FORMULATION TECHNOLOGY FOR BETTER TREATMENT
Stephen Tindal provides reviews strategies for oral formulation selection which can lower attrition rates, and therefore development costs and time to market.
GI/ORAL
Dr David Beach
Accu-Break Pharmaceuticals
ACCU-BREAK’S INNOVATIVE TABLET TECHNOLOGY – 2016 ADVANCEMENTS
David Beach provides a run-down of Accu-Break Pharmaceuticals’ tablet technologies which, among other benefits, allow patients to split tablets readily and reliably.
GI/ORAL
Hans Baer
Evonik
AN INNOVATIVE SMART ORAL DELIVERY TECHNOLOGY FOR PROTEINS AND PEPTIDES
Andrea Engel, Anne Benedikt and Hans Baer explain how their recently introduced new modular platform technology for improving the oral bioavailability of peptides may offer a feasible solution to the problem of compliance with peptide drugs.
GI/ORAL
Dr Cory Berkland
Orbis Biosciences
THE EMERGENCE OF CONTROLLED-RELEASE POWDERS FOR ORAL ADMINISTRATION
Cory Berkland and Nathan Dormer look at what controlled-release powder delivery systems can offer, noting that a rising number of pharmaceutical companies and manufacturing organisations are incorporating controlled-release powder manufacturing to their portfolios.
GI/ORAL
Paul Wismer
SG Balda
DIAL THE DOSE: A CLEVER DISPENSER FOR NON-STERILE LIQUIDS
Paul Wismer explains how Balda's Dial-the-Dose product can help avoid the dangers of accidental overdose from using teaspoon- or tablespoon-based instructions for liquid medications, highlighted in several reports and studies, by improving the accuracy of liquid dosing.
GI/ORAL
Megan Greth
ARx
THIN FILM EVOLVES TO LEVERAGE MUCOSAL DRUG DELIVERY BENEFITS
Megan Greth and Scott Barnhart describe how thin film drug delivery systems are growing in importance as the benefits, such as improved drug bioavailability, reduced adverse events and avoidance of the first pass metabolism, are increasingly being recognised.
GI/ORAL
Rashmi Nair
Dr Reddy's Laboratories
NOVEL ORAL DRUG DELIVERY: INNOVATING TO SIMPLIFY
Rashmi Nair and Praveen Raheja use case studies to illustrate their company’s approach to simplifying existing oral drug delivery systems, including osmotic and matrix tablet technologies.
EXPERT VIEW
Mir Imran
A NOVEL APPROACH TO THE ORAL DELIVERY OF BIOLOGICS, PEPTIDES AND ANTIBODIES
Mir Imran provides an exclusive update on his company's groundbreaking robotic Auto-Pill™, which delivers a pain-free intestinal injection using a dissolvable needle made from materials that can be absorbed or easily passed out of the body.
GI/ORAL
Dr Rick Chan
LTS Lohmann Therapie-Systeme
ORAL THIN FILMS – REALMS OF POSSIBILITY?
Rick Chan, PhD, Executive Scientific Officer, LTS Lohmann Therapy Systems, discusses the fundamentals of transmucosal absorption and how formulation effort and the drug properties influence drug absorption in the buccal cavity.
GI/ORAL
Dr Carmen Popescu
Roquette
WHY ORAL DISINTEGRATING TABLETS?
Carmen Popescu provides an overview of the Orally Disintegrating Tablet (ODT) landscape, describing how these dosage forms can be used to improve and differentiate drug products, different manufacturing methods and how this class of oral delivery system might be applied in the future.
GI/ORAL
Dr John Tillotson
ABITEC Corporation
METHODOLOGIES FOR DEVELOPING s-SEDDS
John Tillotson looks at the various methods available for manufacturing solid self-emulsifying drug delivery systems (s-SEDDS) and explores future possibilities of optimising these methods, which are growing in popularity as they offer advantages over liquids.
CONNECTIVITY
Paul Wismer
SG Balda
SMART PILL DISPENSER – A NEW TOOL FOR IMPROVING PATIENT ADHERENCE
Non-adherence by patients to dosing regimens is a major problem and it is estimated that around 50% of people with chronic disease do not take their medications regularly. This has major costs not only financially but also in increased rates of complications and higher morbidity and mortality.
INTERVIEW
Dr Elizabeth Shen
Colorcon
DR ELIZABETH SHEN, COLORCON
Elizabeth Shen talks taste-masking, from the positive impact on medication adherence, to technical approaches and technology selection, and regulatory considerations.
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