GI/ORAL

CONNECTIVITY

THE TRUSTED TABLET: A NEW LEVEL OF SUPPLY CHAIN SECURITY FROM MASS DIGITALISATION OF MEDICINES

Kelly Boyer, Trent Lund and Barry McDough describe a means of mass digitalising medicines to address the problem of illegal and unauthorised production of pharmaceutical products in a meaningful way.

EARLY INSIGHT

PERSONALISING DRUG PRODUCTS USING 3D PRINTING

Sarah Trenfield and Abdul Basit look at the potential applications of 3D-printing technology to create personalised drug therapies in fields such as multiple drug therapy and paediatric/geriatric care and introduce FabRx’s 3D-printing system, which can produce formulations to suit a variety of situations.

COVID-19 NEWS

Lexaria Bioscience

Lexaria Bioscience Expands Pharma Division for development of Lipophilic Antivirals against COVID-19

Lexaria is to investigate how its patented DehydraTECH drug delivery technology could enhance delivery and effectiveness of certain antiviral drugs in the fight against coronavirus disease COVID-19.  Lexaria intends to expand collaboration with leading laboratories as soon as possible.

EXPERT VIEW

Dr Ulrica Sehlstedt

TRANSFORMING HEALTHCARE – HOW CURATIVE THERAPIES WILL DISRUPT THE MARKET

Ulrica Sehlstedt, Craig Wylie, Thomas Unger, Rebecka Axelsson Wadman, Vikas Kharbanda, and Satoshi Ohara, all members of Arthur D. Little’s Healthcare and Life Sciences Practice, explain how the shift to curative treatments promises to transform the entire healthcare ecosystem. 

RESPIRATORY

Dr Geoffroy Lumay

Granutools

HOW TO GAIN A FULL UNDERSTANDING OF POWDER FLOW PROPERTIES, AND THE BENEFITS OF DOING SO

Geoffroy Lumay, Naveen Mani Tripathi and Filip Francqui show how the association of three recently developed flow measurement techniques can be used to gain valuable insights into powder properties and characteristics.

EXPERT VIEW

Dr Aline Moulin

COMPACTION SIMULATION / INDUSTRIAL PRESS CORRELATION: TWO CASE STUDIES

Aline Moulin and Lucile Kowalski examine two case studies comparing compaction simulation with industrial compression.

EXPERT VIEW

Jamie Clayton

3D PRINTING DRUGS: LEARNING FROM THE PIONEERS

Jamie Clayton reviews the potential of 3D printing as a pharmaceutical production method and looks at the associated implications for formulation development, focusing on powder-based printing. He examines what leading experts now understand about how to specify powder feeds for 3D printing.

INDUSTRIALISATION

Jose Luis Encinas

Qualicaps

QUALI-V EXTRA DRY: A NOVEL CAPSULE FOR DELIVERING HYGROSCOPIC FORMULATIONS

Jose Luis Encinas and Susana Ecenarro explore how the use of Quali-V^® Extra Dry capsules can help improve product stability and, crucially, lead to efficiencies and savings in drug product manufacture.

EXPERT VIEW

Dr Nidhi Prakash Sapkal

ORAL THIN FILMS: NOVEL TECHNOLOGY & ITS CHALLENGES

Presented from both the technology and formulation perspectives, Nidhi Prakash Sapkal and Anwar Siraj Daud discuss the challenges of industrialising oral thin films, a promising but difficult dosage form.

INDUSTRIALISATION

Hugues Benevent

Unither Pharmaceuticals

THE ODTECH PLATFORM: A RANGE OF READY-TO-USE ORAL FORMS

Hugues Benevent and Nathalie Masson introduce the ODtech™ platform technology for oral medications, designed to provide an easy-to-use and ready-to-industrialise solution for tackling the human factors issues of standard oral pills.

EXPERT VIEW

Jonathan Gaik

GO WITH THE FLOW – SOLVING POWDER FLOW CHALLENGES BEFORE PRODUCTION

Jonathan Gaik discusses the various problems in tablet compression that can be caused by not giving due care to powder flow in the development stage and how, by doing so, what would be serious problems at the industrial scale can be solved in advance.

EXPERT VIEW

Dr Damon C Smith

PREVENTION NOT CURE: AVOIDING A EUROPEAN PRESCRIPTION OPIOID EPIDEMIC

Damon Smith, Richard Dart and Christopher Hirst discuss the causes and possible solutions to the prescription opioid epidemic, as well as whether or not Europe is likely to face a similar fate.

GI/ORAL

Cécile Morin

Gattefossé

HIGH SHEAR COATING: A VERSATILE TASTE-MASKING PROCESS

Cécile Morin and Yvonne Rosiaux discuss taste-masking, covering the advantages of Precirol^® ATO 5 and how Gattefossé’s high shear coating process presents an appealing alternative to standard fluid bed techniques.

EXPERT VIEW

Rob Davidson

ORAL FILMS – A MULTI-FACETED DRUG DELIVERY SYSTEM AND DOSAGE FORM

Oral films are a relative newcomer to the drug delivery space, though one with considerable potential. Rob Davidson and Jessica Rousset give an overview of this dosage form, from formulation through manufacturing to future outlook.

GI/ORAL

Dr Anna Malori

Bormioli Pharma

ORAL DRUG RECONSTITUTION: MAKING IT EASY AND ACCURATE VIA PACKAGING INNOVATION

Anna Malori discusses the oft overlooked challenges and difficulties of standard packaging systems for oral medications requiring reconstitution before use.

EXPERT VIEW

Rashmi Nair

THE SCIENCE OF SOLUBILITY AND THE SUCCESS OF AMORPHOUS SOLID DISPERSIONS

Rashmi Nair discusses the persistent challenge presented by poorly soluble drug formulations in oral drug delivery. Furthermore, she goes on to highlight the promise shown by amorphous solid dispersions, despite the difficulties they present.

GI/ORAL

Dr Michael Baumann

EXCIPIENT INNOVATION REQUIRES CLOSE COLLABORATION

Michael Baumann discusses the need for novel excipients in new drug development, the regulatory difficulties inherent to developing novel excipients and methods of innovation using current compendial excipients.

GI/ORAL

Dr Maria Montero Mirabet

Evonik

ADVANCED APPROACHES FOR DELAYED-RELEASE FORMULATIONS

Maria Montero Mirabet and Brigitte Skalsky, both of Evonik Health Care, review advances in delayed-release technology including advances in enteric-coating applications and the use of pulsatile technology to provide tailored lag times.

GI/ORAL

Don Barbieri

SPI Pharma

MEETING THE CHALLENGES OF PAEDIATRIC DOSING

Although paediatric drugs are traditionally administered in a liquid formulation, recent studies suggest that orally disintegrating mini-tablets may be a more accurate, convenient and less messy dosage form. Don Barbieri explores this method and reviews two case studies looking at whether quality standards can be met and the importance of taste in paediatric formulations.

EXPERT VIEW

Dr S Mohan Mohanraj

EVALUATING A NEW MICROSPHERE BASED CONTROLLED-RELEASE DELIVERY SYSTEM

S Mohan Mohanraj and Meir Kende discuss the development of a microsphere based delivery system for an orally administered anthrax vaccine.

GI/ORAL

Aia Malik

Lucideon

THE PRESCRIPTION ABUSE EPIDEMIC: DESIGNING A SOLUTION

Aia Malik and Gemma Budd discuss the journey behind Lucideon’s proprietary iCRTdeter technology which provides tamper-proofing and enhanced safety of pharmaceuticals. It has been used to give abuse-deterrent features to formulations of opioids and highly potent compounds.

GI/ORAL

Dr Carmen Popescu

Roquette

ORALLY DISINTEGRATING FILMS FOR THE DELIVERY OF BIOTHERAPEUTICS & NANO / MICROPARTICLE FORMULATIONS

Carmen Popescu summarises the benefits and applications of orally dissolving film dosage forms, with claims supported by two case studies, one demonstrating the suitability of ODFs for the delivery of micro and nanoparticles, the other showing how this property of ODFs exhibits promise as a next-generation immunisation system.

GI/ORAL

Dr Nathan Dormer

Orbis Biosciences

SINGLE-STEP FUNCTIONAL COATINGS FOR INCREASED EFFICIENCIES

In this article about oral drug innovation, Cory Berkland and Nathan Dormer focus on how enterics and reverse enterics are applied into dosage forms, and discuss the future of this class of drug formulation technology.

GI/ORAL

Dr Sejal R Ranmal

Intract Pharma

OPPORTUNITIES & INNOVATIONS IN COLONIC DRUG DELIVERY

Sejal R Ranmal, Vipul Yadav and Abdul W Basit describe recent insights into the physiology of the colon, advantages of targeting drug release to the colon and introduce Phloral®, Intract’s unique system for achieving drug release in the colon successfully and consistently.

EXPERT VIEW

Dr Nozer Mehta

TECHNOLOGIES & CLINICAL STUDIES FOR THE ORAL DELIVERY OF CALCITONIN

Nozer Mehta, James P Gilligan and William Stern summarise the different technologies that have been in development for oral delivery of peptides through the gastro-intestinal mucosal surfaces via the transcellular or the paracellular pathways and describe the results of several long-term clinical studies on the oral delivery of salmon calcitonin.

EXPERT VIEW

Stephen Tindal

SELECTING OPTIMAL FORMULATION TECHNOLOGY FOR BETTER TREATMENT

Stephen Tindal provides reviews strategies for oral formulation selection which can lower attrition rates, and therefore development costs and time to market.

GI/ORAL

Dr David Beach

Accu-Break Pharmaceuticals

ACCU-BREAK’S INNOVATIVE TABLET TECHNOLOGY – 2016 ADVANCEMENTS

David Beach provides a run-down of Accu-Break Pharmaceuticals’ tablet technologies which, among other benefits, allow patients to split tablets readily and reliably.

GI/ORAL

Hans Baer

Evonik

AN INNOVATIVE SMART ORAL DELIVERY TECHNOLOGY FOR PROTEINS AND PEPTIDES

Andrea Engel, Anne Benedikt and Hans Baer explain how their recently introduced new modular platform technology for improving the oral bioavailability of peptides may offer a feasible solution to the problem of compliance with peptide drugs.

GI/ORAL

Dr Cory Berkland

Orbis Biosciences

THE EMERGENCE OF CONTROLLED-RELEASE POWDERS FOR ORAL ADMINISTRATION

Cory Berkland and Nathan Dormer look at what controlled-release powder delivery systems can offer, noting that a rising number of pharmaceutical companies and manufacturing organisations are incorporating controlled-release powder manufacturing to their portfolios.

GI/ORAL

Paul Wismer

SG Balda

DIAL THE DOSE: A CLEVER DISPENSER FOR NON-STERILE LIQUIDS

Paul Wismer explains how Balda's Dial-the-Dose product can help  avoid the dangers of accidental overdose from using teaspoon- or tablespoon-based instructions for liquid medications,  highlighted in several reports and studies, by improving the accuracy of liquid dosing.

GI/ORAL

Megan Greth

ARx

THIN FILM EVOLVES TO LEVERAGE MUCOSAL DRUG DELIVERY BENEFITS

Megan Greth and Scott Barnhart describe how thin film drug delivery systems are growing in importance as the benefits, such as improved drug bioavailability, reduced adverse events and avoidance of the first pass metabolism, are increasingly being recognised.

GI/ORAL

Rashmi Nair

Dr Reddy's Laboratories

NOVEL ORAL DRUG DELIVERY: INNOVATING TO SIMPLIFY

Rashmi Nair and Praveen Raheja use case studies to illustrate their company’s approach to simplifying existing oral drug delivery systems, including osmotic and matrix tablet technologies.

EXPERT VIEW

Mir Imran

A NOVEL APPROACH TO THE ORAL DELIVERY OF BIOLOGICS, PEPTIDES AND ANTIBODIES

Mir Imran provides an exclusive update on his company's groundbreaking robotic Auto-Pill™, which delivers a pain-free intestinal injection using a dissolvable needle made from materials that can be absorbed or easily passed out of the body. 

GI/ORAL

Dr Rick Chan

LTS Lohmann Therapie-Systeme

ORAL THIN FILMS – REALMS OF POSSIBILITY?

Rick Chan, PhD, Executive Scientific Officer, LTS Lohmann Therapy Systems, discusses the fundamentals of transmucosal absorption and how formulation effort and the drug properties influence drug absorption in the buccal cavity.

GI/ORAL

Dr Carmen Popescu

Roquette

WHY ORAL DISINTEGRATING TABLETS?

Carmen Popescu provides an overview of the Orally Disintegrating Tablet (ODT) landscape, describing how these dosage forms can be used to improve and differentiate drug products, different manufacturing methods and how this class of oral delivery system might be applied in the future.

GI/ORAL

Dr John Tillotson

ABITEC Corporation

METHODOLOGIES FOR DEVELOPING s-SEDDS

John Tillotson looks at the various methods available for manufacturing solid self-emulsifying drug delivery systems (s-SEDDS) and explores future possibilities of optimising these methods, which are growing in popularity as they offer advantages over liquids.

CONNECTIVITY

Paul Wismer

SG Balda

SMART PILL DISPENSER – A NEW TOOL FOR IMPROVING PATIENT ADHERENCE

Non-adherence by patients to dosing regimens is a major problem and it is estimated that around 50% of people with chronic disease do not take their medications regularly. This has major costs not only financially but also in increased rates of complications and higher morbidity and mortality.

INTERVIEW

Dr Elizabeth Shen

Colorcon

DR ELIZABETH SHEN, COLORCON

Elizabeth Shen talks taste-masking, from the positive impact on medication adherence, to technical approaches and technology selection, and regulatory considerations.