INJECTION

PREFILLED SYRINGES

Aurelie Pager

BD (Becton Dickinson & Company)

8 MM NEEDLE – IMPROVING SUBCUTANEOUS CHRONIC DRUG DELIVERY

Aurelie Pager describes how reducing needle length can improve the risk profile of subcutaneous injections and can make injecting viscous formulations easier and quicker, and highlights BD’s development programme for an innovative shorter needle with ultra-thin walls for prefilled syringes.

EXPERT VIEW

Chris Franzese

Matchstick

CO-PACKAGED COMPONENTS IMPROVE PATIENT EXPERIENCE AND ENSURE CONSISTENT DRUG DELIVERY

Chris Franzese and Amy Rinaldi explore the challenges and benefits of co-packaging for manufacturers, healthcare workers and patients.

CONNECTIVITY

Dr Iain Simpson

Phillips-Medisize

HOW CONNECTIVITY ADDS VALUE TO INJECTABLE DRUG DELIVERY DEVICES

In the context of the growing shift in emphasis from improving adherence to the better outcomes that can arise from doing so, Iain Simpson discusses why connectivity is becoming increasingly important in injectable drug delivery, and how it can benefit patients, providers and pharmaceutical manufacturers.

CONNECTIVITY

Chantal Wierckx

Biocorp

ADDING VALUE TO PREFILLED SYRINGES: SAFETY AND CONNECTIVITY

Chantal Wierckx and Arnaud Guillet provide an update on Newguard™, Biocorp’s integrated safety device for prefilled syringes, and explore the possible advantages connectivity can bring in the context of traceability for anti-counterfeiting, in clinical trials and in vaccination campaigns.

PREFILLED SYRINGES

Joe Reynolds

Noble

DEVELOPING DEMONSTRATORS TO INCREASE PATIENT CONFIDENCE AND REDUCE ANXIETY

Joe Reynolds discusses the value of demonstrators for making patients comfortable and effective with their prefilled syringe, leading to a significant improvement in treatment adherence and patient quality of life.

PREFILLED SYRINGES

Mr Maximilian Vogl

Gerresheimer

Gerresheimer Expands Gx RTF^® ClearJect^® Product Line

Maximilian Vogl describes how Gerresheimer is expanding its range of prefillable polymer syringes to include a new product: the Gx RTF^® ClearJect^® polymer syringe, 2.25 mL.

WEARABLES

Matthew Huddleston

Enable Injections

KEY CHALLENGES IN SUCCESSFUL WEARABLE DRUG DELIVERY & PATIENT SELF-ADMINISTRATION

Matthew Huddleston, Andrew Eibling and Jennifer King look at the key challenges involved in successful wearable drug delivery technology and patient self-administration.

WEARABLES

Tsachi Shaked

E3D – Elcam Drug Delivery Devices

EVOLUTION OF AN ON-BODY BOLUS INJECTOR: FROM DRUG-SPECIFIC DEVICE TO PLATFORM

Tsachi Shaked introduces E3D’s On-body Bolus Injector, OBI, a versatile platform that uses gas generating microcells as its engine, has no electromechanical components, and only one moving part.

WEARABLES

Hans Peter Manser

Weibel CDS

LARGE-VOLUME WEARABLE DRUG DELIVERY: A VISION BECOMES REALITY

Hans Peter Manser, Christoph Egloff and Martin C King introduce LV DDS , a flexible-form, low-profile wearable injector platform, for large-volume drug delivery.

EXPERT VIEW

Manuel Scherer

SHARING IS CARING: POLYMER SUPPLIERS AS MEDICAL DEVICE DEVELOPMENT PARTNERS

Manuel Scherer looks at whether the advent of wearable injectors calls for a more collaborative approach between polymer suppliers and medical device developers.

EXPERT VIEW

Dr Neal Carty

WEARABLE INJECTORS: CHOOSING & TESTING OPTIMAL ADHESIVES

Neal Carty and Deepak Prakash highlight the importance of choosing and testing adhesives for optimal wearable drug delivery device performance.

WEARABLES

Steven Kaufman

Stevanato Group

CAN WEARABLE DEVICES BRIDGE THE GAP BETWEEN PEN INJECTOR AND PUMP?

Steven Kaufman and Paolo Golfetto explore the potential for wearable injectors to be disruptive technologies in the drug delivery market.

WEARABLES

Beth DiLauri

BD (Becton Dickinson & Company)

THE CHANGING DRUG DELIVERY PARADIGM

Beth DiLauri sets out the fundamental case for the adoption of wearable injectors, outlines the specific barriers they overcome and describes how the design and development of the BD Libertas™ wearable injector platform make it an attractive proposal for pharma companies.

WEARABLES

Joe Reynolds

Noble

TRAINING PATIENTS IN THE USE OF WEARABLE INJECTORS

Joe Reynolds highlights the projected growth in popularity of wearable injector devices, and shows that it is imperative for healthcare providers (HCPs) both to train their patients properly in the office, and offer training devices that patients can take home and practice with. 

EXPERT VIEW

Dominique Bauert

PRIMARY PACKAGING FOR WEARABLE INJECTION DEVICES

Dominique Bauert and Anil Kumar Busimi provide an overview of existing wearable injector solutions and new requirements, with a focus on the role of the primary packaging inside the devices.

WEARABLES

Claus Schmidt Moeller

Subcuject

DEVELOPMENT OF AN OSMOTIC LARGER VOLUME WEARABLE BOLUS INJECTOR

Claus Schmidt Moeller provides an overview of the mechanism, functionality and applications of the company’s osmotic, single-use, low-cost, versatile wearable bolus injector.

WEARABLES

Rolf Rihs

Mikron Automation

SCALABLE ASSEMBLY SOLUTIONS – FULLY INTEGRATED, TRULY GLOBAL

Rolf Rihs and Jean-François Bauer look at how Mikron has specialised in flexible, modular assembly solutions that are easy to evolve during the different stages of a product lifecycle: from development through to fully automated, maximum-performance production.

WEARABLES

Hiroki Hasegawa

Mitsubishi Gas Chemical

ADVANCES IN MULTILAYER TECHNOLOGY FOR WEARABLE INJECTOR PRIMARY PACKAGING

Hiroki Hasegawa and Tomohiro Suzuki discuss how multilayer technology used in the drinks bottle industry can be used to create syringes and vials for biologics, avoiding problems such as oxidation and absorption that occur with other materials.

WEARABLES

Ian Thompson

Ypsomed

LARGE-VOLUME PATCH-INJECTION VIA YPSODOSE: SIMPLER FOR PHARMA COMPANIES & PATIENTS

Ian Thompson updates us on the company’s prefilled large-volume patch injector platform, YpsoDose, which simplifies the approach to wearable patch injectors for both pharma companies and patients.

WEARABLES

Sandra De Haan

Sensile Medical

COMPANY SHOWCASE: Sensile Medical

Sensile Medical has achieved a lot since its acquisition by Gerresheimer last year. Here they provide an update on two recent projects: the recent market launch of our first micropump, an infusion pump for Parkinson’s disease patients; and our latest project with SQ Innovation for a 3 mL furosemide patch pump.

WEARABLES

Mindy Katz

Sorrel Medical

A VIAL-BASED SOLUTION FOR WEARABLE DRUG DELIVERY

Mindy Katz and Michael Ratigan describe how, due to the inherent challenges of integrating vials into wearable devices, there has not been a viable, patient-centric option for wearable devices using vials ... until now.

WEARABLES

Victoria Morgan

West Pharmaceutical Services

HOW LARGE-VOLUME WEARABLES REVOLUTIONISE THE PATIENT EXPERIENCE

Victoria Morgan looks at how the combination of large-volume medicines and the trend for wearable devices is transforming life for patients, highlighting the company's new-generation SmartDose 10 mL platform.

WEARABLES

Catherine Thacker

ATS Automation

MITIGATING RISK TO DELIVER SUCCESS IN HIGH-VOLUME WEARABLE DEVICES

Catherine Thacker and Bill Jaworski discuss risk reduction solutions in the manufacturing architecture for wearable injectors, including an example where autonomous intelligent vehicles and ATS‘s real-time industrial IoT manufacturing intelligence system, Illuminate®, were employed.

EXPERT VIEW

Michael Penman

THE CHALLENGES OF VERIFYING A WEARABLE INFUSOR

Michael Penman shows why it is important to verify body-worn infusor performance, highlighting the challenges and learnings from an example where Team Consulting was tasked with the design and verification of one such wearable device.

EXPERT VIEW

Cory Costantino

A QUICK GUIDE TO USABILITY FOR WEARABLE INJECTORS

Cory Costantino and Lauren Fennelly list some typical steps a user might take while using wearable injectors, providing tips and points to note at each step, including design tips that might pre-empt potential interaction problems, and points to consider when conducting usability testing.

CONFERENCE SHOWCASE

Dr Falk Klar

PDA

2019 PDA UNIVERSE OF PRE-FILLED SYRINGES AND INJECTION DEVICES PREVIEW

PDA Europe presents the 16th edition of its signature event Universe of Pre-filled Syringes & Injection Devices – an important conference for people working in the fields of parenteral drug, and device, development, covering solutions to challenges regarding new developments, and regulatory and industry trends.

INDUSTRIALISATION

Gilbert Fluetsch

SHL Group

EXPANDING AUTOMATION CAPACITY FOR HIGH AND LOW VOLUMES

Gilbert Fluetsch and Lucy Chung look at how automation and assembly services can best evolve and adapt to industry standards and market demands, whilst delivering consistently at high quality and in a timely manner.

INDUSTRIALISATION

Berthold Schopferer

Zahoransky

Z.BLIZZARD AUTOMATION SYSTEM – IT DOESN’T GET MORE TAILOR-MADE THAN THIS

Berthold Schopferer explains how the Zahoransky’s integrated syringe manufacturing and assembly equipment allows maximum customisation and full customer involvement.

INTERVIEW

Cecile Halte

BD (Becton Dickinson & Company)

Cecile Halte, BD

In this interview, Cécile Halté, Senior Program Manager, Acute Care Segment, for BD Medical – Pharmaceutical Systems. discusses validation studies of the BD Sterifill Advance™ plastic prefilled syringe, which is intended for use in the hospital setting by healthcare professionals either for manual bolus injections, or with infusion pumps.

INDUSTRIALISATION

Michael Wiglenda

Gerresheimer

A FIVE-STEP APPROACH TO INNOVATION IN DRUG DELIVERY SYSTEMS

Michael Wiglenda explains Gerresheimer’s industrialisation offering and the five-step Gate-Model that guides its innovation process.

INDUSTRIALISATION

Steve Wardell

ATS Automation

AUTOMATING PREVIOUSLY IMPOSSIBLE MANUAL INSPECTIONS USING MACHINE LEARNING & CONCURRENT VALIDATION

Steve Wardell and Catherine Thacker explore how machine learning technology is enabling the automation of challenging, or previously impossible, manual inspections.

EXPERT VIEW

Shaul Eitan

CUSTOMISED INFUSION PUMPS: THE FUTURE OF SELF-ADMINISTRATION?

Shaul Eitan explores the challenges of home infusion and examines how customisation and connectivity could help provide a solution.

CONNECTIVITY

Dr Andreas Schneider

Ypsomed

I SPY WITH MY LITTLE EYE: EYE TRACKING DRIVES PATIENT-CENTRED DEVELOPMENT OF CONNECTED SYSTEMS

The development of connected self-injection systems is driving industry to rethink its current approaches to patient-centred new product development. Andreas Schneider summarises a recent field study that used eye tracking for the formative usability testing of SmartPilot for YpsoMate.

CONNECTIVITY

Dr Ramin Rafiei

SHL Group

MACRO TRENDS ACCELERATING THE ADOPTION OF CONNECTIVITY IN DRUG DELIVERY

Ramin Rafiei argues that connected therapeutics – the augmentation of drugs through sensors and connectivity – are now a clinical source for real-world data and provide an opportunity to bridge the efficacy-to-effectiveness gap. This next frontier in drug delivery, powered by connected therapeutics, will be data-driven, personalised, outcomes-based and accessible.

CONNECTIVITY

Eric Dessertenne

Biocorp

COMPLETING ITS TRANSITION FROM GENESIS TO MATURITY, BIOCORP OPENS NEW HORIZONS

As Biocorp prepares for the market launch of its connected injector pen add-on, Mallya, Eric Dessertenne and Arnaud Guillet share insights about key steps in the company’s development. The article discusses the many partnership Biocorp has entered in to, and includes a mini-interview with Sergio Monti, Plant Manager for one such partner, V.A.R.I.

CONNECTIVITY

Thierry Decock

Nemera

CONNECTED DEVICES – MEDICATION DELIVERY JUST GOT PERSONAL

Thierry Decock and Hadrien Gremillet explore how the obstacles to the adoption of connectivity can be overcome and how connected devices can deliver truly patient-centric care that will clearly improve adherence rates, whilst demonstrating a clear cost benefit to the pharmaceutical partner.