WEARABLES

WEARABLES

DRUG DELIVERY DESIGNED TO IMPROVE THE PATIENT EXPERIENCE

Jennifer King looks at the delivery challenges of novel therapies for chronic diseases using a specific patient’s story as an example, going on to highlight the ways in which a novel device approach could make all the difference for patients.

WEARABLES

NEXT-GENERATION WEARABLE DELIVERY DEVICES FOR LARGE-VOLUME BIOLOGICS

Thomas Mayer discusses Sonceboz’s platform of wearable injection devices for large-volume biologics, which can follow drugs from clinical trials to commercial phase through lifecycle management, which reduces risk and speeds time to market.

EXPERT VIEW

Dr Paolo Fiorini

LARGE-VOLUME INJECTORS: RISE IN BIOLOGICS BRINGS CHALLENGES

Developing devices capable of delivering highly viscous biologic drug formulations at high volumes does not come without its challenges. Paolo Fiorini, Gerard Linnane, Michael Kiely, Maciej Grygorczuk and Joshua Coyne discuss these challenges and the merits of various drive solutions.

WEARABLES

Dr Temitope Sodunke

BD (Becton Dickinson & Company)

ADDRESSING THE EVOLVING NEEDS OF VARIABLE DRUG DELIVERY REGIMENS

Temitope Sodunke introduces the BD Evolve™ On-body Injector and describes how the device is designed specifically to address the rapidly evolving needs of the pharma industry and meet patient requirements.

EXPERT VIEW

Stephen Augustyn

HOW TO DESIGN A BODY-WORN INJECTOR

Body-worn injectors require you to understand your user, your drug and your technology – and there are numerous pitfalls for the unwary. Stephen Augustyn shares some insights.

INJECTION

Tibor Hlobik

West Pharmaceutical Services

SIMPLIFYING THE PROCESS OF DEVELOPING PREFILLED SYRINGES

Tibor Hlobik describes how the use of cyclic olefin polymer delivery systems is gaining in popularity because of the benefits they have over glass systems for complex drug applications, and explains what this advance in technology can offer drug manufacturers.

WEARABLES

Matthew Huddleston

Enable Injections

KEY CHALLENGES IN SUCCESSFUL WEARABLE DRUG DELIVERY & PATIENT SELF-ADMINISTRATION

Matthew Huddleston, Andrew Eibling and Jennifer King look at the key challenges involved in successful wearable drug delivery technology and patient self-administration.

WEARABLES

Tsachi Shaked

E3D – Elcam Drug Delivery Devices

EVOLUTION OF AN ON-BODY BOLUS INJECTOR: FROM DRUG-SPECIFIC DEVICE TO PLATFORM

Tsachi Shaked introduces E3D’s On-body Bolus Injector, OBI, a versatile platform that uses gas generating microcells as its engine, has no electromechanical components, and only one moving part.

WEARABLES

Hans Peter Manser

Weibel CDS

LARGE-VOLUME WEARABLE DRUG DELIVERY: A VISION BECOMES REALITY

Hans Peter Manser, Christoph Egloff and Martin C King introduce LV DDS , a flexible-form, low-profile wearable injector platform, for large-volume drug delivery.

EXPERT VIEW

Manuel Scherer

SHARING IS CARING: POLYMER SUPPLIERS AS MEDICAL DEVICE DEVELOPMENT PARTNERS

Manuel Scherer looks at whether the advent of wearable injectors calls for a more collaborative approach between polymer suppliers and medical device developers.

EXPERT VIEW

Dr Neal Carty

WEARABLE INJECTORS: CHOOSING & TESTING OPTIMAL ADHESIVES

Neal Carty and Deepak Prakash highlight the importance of choosing and testing adhesives for optimal wearable drug delivery device performance.

WEARABLES

Steven Kaufman

Stevanato Group

CAN WEARABLE DEVICES BRIDGE THE GAP BETWEEN PEN INJECTOR AND PUMP?

Steven Kaufman and Paolo Golfetto explore the potential for wearable injectors to be disruptive technologies in the drug delivery market.

WEARABLES

Beth DiLauri

BD (Becton Dickinson & Company)

THE CHANGING DRUG DELIVERY PARADIGM

Beth DiLauri sets out the fundamental case for the adoption of wearable injectors, outlines the specific barriers they overcome and describes how the design and development of the BD Libertas™ wearable injector platform make it an attractive proposal for pharma companies.

WEARABLES

Joe Reynolds

Noble

TRAINING PATIENTS IN THE USE OF WEARABLE INJECTORS

Joe Reynolds highlights the projected growth in popularity of wearable injector devices, and shows that it is imperative for healthcare providers (HCPs) both to train their patients properly in the office, and offer training devices that patients can take home and practice with. 

EXPERT VIEW

Dominique Bauert

PRIMARY PACKAGING FOR WEARABLE INJECTION DEVICES

Dominique Bauert and Anil Kumar Busimi provide an overview of existing wearable injector solutions and new requirements, with a focus on the role of the primary packaging inside the devices.

WEARABLES

Claus Schmidt Moeller

Subcuject

DEVELOPMENT OF AN OSMOTIC LARGER VOLUME WEARABLE BOLUS INJECTOR

Claus Schmidt Moeller provides an overview of the mechanism, functionality and applications of the company’s osmotic, single-use, low-cost, versatile wearable bolus injector.

WEARABLES

Rolf Rihs

Mikron Automation

SCALABLE ASSEMBLY SOLUTIONS – FULLY INTEGRATED, TRULY GLOBAL

Rolf Rihs and Jean-François Bauer look at how Mikron has specialised in flexible, modular assembly solutions that are easy to evolve during the different stages of a product lifecycle: from development through to fully automated, maximum-performance production.

WEARABLES

Hiroki Hasegawa

Mitsubishi Gas Chemical

ADVANCES IN MULTILAYER TECHNOLOGY FOR WEARABLE INJECTOR PRIMARY PACKAGING

Hiroki Hasegawa and Tomohiro Suzuki discuss how multilayer technology used in the drinks bottle industry can be used to create syringes and vials for biologics, avoiding problems such as oxidation and absorption that occur with other materials.

WEARABLES

Ian Thompson

Ypsomed

LARGE-VOLUME PATCH-INJECTION VIA YPSODOSE: SIMPLER FOR PHARMA COMPANIES & PATIENTS

Ian Thompson updates us on the company’s prefilled large-volume patch injector platform, YpsoDose, which simplifies the approach to wearable patch injectors for both pharma companies and patients.

WEARABLES

Sandra De Haan

Sensile Medical

COMPANY SHOWCASE: Sensile Medical

Sensile Medical has achieved a lot since its acquisition by Gerresheimer last year. Here they provide an update on two recent projects: the recent market launch of our first micropump, an infusion pump for Parkinson’s disease patients; and our latest project with SQ Innovation for a 3 mL furosemide patch pump.

WEARABLES

Mindy Katz

Sorrel Medical

A VIAL-BASED SOLUTION FOR WEARABLE DRUG DELIVERY

Mindy Katz and Michael Ratigan describe how, due to the inherent challenges of integrating vials into wearable devices, there has not been a viable, patient-centric option for wearable devices using vials ... until now.

WEARABLES

Victoria Morgan

West Pharmaceutical Services

HOW LARGE-VOLUME WEARABLES REVOLUTIONISE THE PATIENT EXPERIENCE

Victoria Morgan looks at how the combination of large-volume medicines and the trend for wearable devices is transforming life for patients, highlighting the company's new-generation SmartDose 10 mL platform.

WEARABLES

Catherine Thacker

ATS Automation

MITIGATING RISK TO DELIVER SUCCESS IN HIGH-VOLUME WEARABLE DEVICES

Catherine Thacker and Bill Jaworski discuss risk reduction solutions in the manufacturing architecture for wearable injectors, including an example where autonomous intelligent vehicles and ATS‘s real-time industrial IoT manufacturing intelligence system, Illuminate®, were employed.

EXPERT VIEW

Michael Penman

THE CHALLENGES OF VERIFYING A WEARABLE INFUSOR

Michael Penman shows why it is important to verify body-worn infusor performance, highlighting the challenges and learnings from an example where Team Consulting was tasked with the design and verification of one such wearable device.

EXPERT VIEW

Cory Costantino

A QUICK GUIDE TO USABILITY FOR WEARABLE INJECTORS

Cory Costantino and Lauren Fennelly list some typical steps a user might take while using wearable injectors, providing tips and points to note at each step, including design tips that might pre-empt potential interaction problems, and points to consider when conducting usability testing.

CONFERENCE SHOWCASE

Dr Falk Klar

PDA

2019 PDA UNIVERSE OF PRE-FILLED SYRINGES AND INJECTION DEVICES PREVIEW

PDA Europe presents the 16th edition of its signature event Universe of Pre-filled Syringes & Injection Devices – an important conference for people working in the fields of parenteral drug, and device, development, covering solutions to challenges regarding new developments, and regulatory and industry trends.

CONNECTIVITY

Thierry Decock

Nemera

CONNECTED DEVICES – MEDICATION DELIVERY JUST GOT PERSONAL

Thierry Decock and Hadrien Gremillet explore how the obstacles to the adoption of connectivity can be overcome and how connected devices can deliver truly patient-centric care that will clearly improve adherence rates, whilst demonstrating a clear cost benefit to the pharmaceutical partner.

WEARABLES

Jesper Roested

Subcuject

A PATIENT CENTRIC AND PHARMA COMPANY CENTRIC PREFILLED WEARABLE BOLUS INJECTOR

Jesper Roested explains why the pharma/biotech drug development process often means device selection occurs after Phase II despite the advantages of earlier selection being well understood, and how this then precludes the selection of novel primary packaging and delivery systems.

WEARABLES

Victoria Morgan

West Pharmaceutical Services

ALTERING PATIENT TREATMENT: HOW SC DELIVERY CAN HELP PATIENTS MANAGE CHRONIC CONDITIONS

Victoria Morgan looks at the benefits of combining an active pharmaceutical product with a novel subcutaneous delivery device, and highlights some of the partnerships West has with biopharmaceutical and other companies, which have led to market launches of products incorporating its on-body delivery system.

EXPERT VIEW

Jennifer King

PATIENT TOLERABILITY WITH HIGH-VISCOSITY, LARGE-VOLUME SUBCUTANEOUS INFUSIONS

Jennifer King and Matthew J Huddleston discuss the advantages of subcutaneous drug delivery and how these have yet to be fully harnessed in currently marketed therapeutics.

PREFILLED SYRINGES

Dr Eric Chappel

Debiotech

LOW-COST DISPOSABLE WEARABLE INJECTOR PLATFORM FOR LARGE VOLUMES OF VISCOUS DRUGS

Eric Chappel, Dimitry Dumont-Fillon and Laurent-Dominique Piveteau discuss Debiotech’s novel wearable injector technology, which utilises a propellant vapour system to drive the injection, making the device both space- and cost-efficient.

PREFILLED SYRINGES

Mindy Katz

Sorrel Medical

UV STERILISATION & THE CASE FOR PREFILLED & PRELOADED DRUG DELIVERY SYSTEMS

Mindy Katz and Ori Ben-David review the different fill form configurations of drug delivery devices, outlining the importance of the prefilled and preloaded device configuration for self-administering patients.

EXPERT VIEW

Charlotte Harvey

HOW SAFETY FEATURES MAKE OR BREAK INFUSION PUMP DESIGN

Charlotte Harvey and Tim Frearson overview the safety systems required when designing an infusion pump system, with a focus on free-flow prevention, occlusion detection and air-in-line detection.

PREFILLED SYRINGES

Hans Peter Manser

Weibel CDS

LYCAJECT: AUTOMATIC RECONSTITUTION PATCH INJECTOR

Hans Peter Manser, Christoph Egloff and Martin C King introduce the LyCaJect Patch Injector, Weibel CDS’ offering in the field of wearable injectors, with automatic reconstitution as a headline feature.

WEARABLES

Mindy Katz

Sorrel Medical

PREFILLED WEARABLE DRUG DELIVERY: HARNESSING TECHNOLOGY FOR PATIENT & PARTNER CENTRICITY

Mindy Katz describes in detail the company’s journey from identifying a clear market need to development and commercialisation of Sorrel’s prefilled and preloaded wearable injection device.

WEARABLES

Jesper Roested

Subcuject

WEARABLE INJECTORS: THE PERCEPTION OF INHERENT EXPENSE AND COMPLEXITY

There is a widespread belief that wearable injectors are too expensive and complex to really take off as a commercially viable method of drug delivery. Jesper Roested tackles the causes of this belief, and explains why it is not truly the case.

EXPERT VIEW

Paul Jansen

2014 TO 2018: AN UPDATE ON THE STATE OF WEARABLE INJECTORS

Looking back on the developments in large volume injectors since his article in ONdrugDelivery’s 2014 issue on wearable injectors, Paul Jansen reflects on the state of this technology space today, how it has progressed and the value it is likely to offer.

WEARABLES

Dr Jeannie Joughin

Enable Injections

BIOLOGIC DRUGS AND THEIR DELIVERY SYSTEMS: A SYMBIOSIS KEY TO COMMERCIAL SUCCESS

Jeannie Joughin discusses the ever-growing importance of the delivery system in the biologic combination product area, highlighting how it is the delivery system, not the drug, that defines the patient experience.