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ORAL
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WEARABLES
WEARABLES
DRUG DELIVERY DESIGNED TO IMPROVE THE PATIENT EXPERIENCE
Jennifer King looks at the delivery challenges of novel therapies for chronic diseases using a specific patient’s story as an example, going on to highlight the ways in which a novel device approach could make all the difference for patients.
WEARABLES
NEXT-GENERATION WEARABLE DELIVERY DEVICES FOR LARGE-VOLUME BIOLOGICS
Thomas Mayer discusses Sonceboz’s platform of wearable injection devices for large-volume biologics, which can follow drugs from clinical trials to commercial phase through lifecycle management, which reduces risk and speeds time to market.
EXPERT VIEW
Dr Paolo Fiorini
LARGE-VOLUME INJECTORS: RISE IN BIOLOGICS BRINGS CHALLENGES
Developing devices capable of delivering highly viscous biologic drug formulations at high volumes does not come without its challenges. Paolo Fiorini, Gerard Linnane, Michael Kiely, Maciej Grygorczuk and Joshua Coyne discuss these challenges and the merits of various drive solutions.
WEARABLES
Dr Temitope Sodunke
BD (Becton Dickinson & Company)
ADDRESSING THE EVOLVING NEEDS OF VARIABLE DRUG DELIVERY REGIMENS
Temitope Sodunke introduces the BD Evolve™ On-body Injector and describes how the device is designed specifically to address the rapidly evolving needs of the pharma industry and meet patient requirements.
EXPERT VIEW
Stephen Augustyn
HOW TO DESIGN A BODY-WORN INJECTOR
Body-worn injectors require you to understand your user, your drug and your technology – and there are numerous pitfalls for the unwary. Stephen Augustyn shares some insights.
INJECTION
Tibor Hlobik
West Pharmaceutical Services
SIMPLIFYING THE PROCESS OF DEVELOPING PREFILLED SYRINGES
Tibor Hlobik describes how the use of cyclic olefin polymer delivery systems is gaining in popularity because of the benefits they have over glass systems for complex drug applications, and explains what this advance in technology can offer drug manufacturers.
WEARABLES
Matthew Huddleston
Enable Injections
KEY CHALLENGES IN SUCCESSFUL WEARABLE DRUG DELIVERY & PATIENT SELF-ADMINISTRATION
Matthew Huddleston, Andrew Eibling and Jennifer King look at the key challenges involved in successful wearable drug delivery technology and patient self-administration.
WEARABLES
Tsachi Shaked
E3D – Elcam Drug Delivery Devices
EVOLUTION OF AN ON-BODY BOLUS INJECTOR: FROM DRUG-SPECIFIC DEVICE TO PLATFORM
Tsachi Shaked introduces E3D’s On-body Bolus Injector, OBI, a versatile platform that uses gas generating microcells as its engine, has no electromechanical components, and only one moving part.
WEARABLES
Hans Peter Manser
Weibel CDS
LARGE-VOLUME WEARABLE DRUG DELIVERY: A VISION BECOMES REALITY
Hans Peter Manser, Christoph Egloff and Martin C King introduce LV DDS , a flexible-form, low-profile wearable injector platform, for large-volume drug delivery.
EXPERT VIEW
Manuel Scherer
SHARING IS CARING: POLYMER SUPPLIERS AS MEDICAL DEVICE DEVELOPMENT PARTNERS
Manuel Scherer looks at whether the advent of wearable injectors calls for a more collaborative approach between polymer suppliers and medical device developers.
EXPERT VIEW
Dr Neal Carty
WEARABLE INJECTORS: CHOOSING & TESTING OPTIMAL ADHESIVES
Neal Carty and Deepak Prakash highlight the importance of choosing and testing adhesives for optimal wearable drug delivery device performance.
WEARABLES
Steven Kaufman
Stevanato Group
CAN WEARABLE DEVICES BRIDGE THE GAP BETWEEN PEN INJECTOR AND PUMP?
Steven Kaufman and Paolo Golfetto explore the potential for wearable injectors to be disruptive technologies in the drug delivery market.
WEARABLES
Beth DiLauri
BD (Becton Dickinson & Company)
THE CHANGING DRUG DELIVERY PARADIGM
Beth DiLauri sets out the fundamental case for the adoption of wearable injectors, outlines the specific barriers they overcome and describes how the design and development of the BD Libertas™ wearable injector platform make it an attractive proposal for pharma companies.
WEARABLES
Joe Reynolds
Noble
TRAINING PATIENTS IN THE USE OF WEARABLE INJECTORS
Joe Reynolds highlights the projected growth in popularity of wearable injector devices, and shows that it is imperative for healthcare providers (HCPs) both to train their patients properly in the office, and offer training devices that patients can take home and practice with.
EXPERT VIEW
Dominique Bauert
PRIMARY PACKAGING FOR WEARABLE INJECTION DEVICES
Dominique Bauert and Anil Kumar Busimi provide an overview of existing wearable injector solutions and new requirements, with a focus on the role of the primary packaging inside the devices.
WEARABLES
Claus Schmidt Moeller
Subcuject
DEVELOPMENT OF AN OSMOTIC LARGER VOLUME WEARABLE BOLUS INJECTOR
Claus Schmidt Moeller provides an overview of the mechanism, functionality and applications of the company’s osmotic, single-use, low-cost, versatile wearable bolus injector.
WEARABLES
Rolf Rihs
Mikron Automation
SCALABLE ASSEMBLY SOLUTIONS – FULLY INTEGRATED, TRULY GLOBAL
Rolf Rihs and Jean-François Bauer look at how Mikron has specialised in flexible, modular assembly solutions that are easy to evolve during the different stages of a product lifecycle: from development through to fully automated, maximum-performance production.
WEARABLES
Hiroki Hasegawa
Mitsubishi Gas Chemical
ADVANCES IN MULTILAYER TECHNOLOGY FOR WEARABLE INJECTOR PRIMARY PACKAGING
Hiroki Hasegawa and Tomohiro Suzuki discuss how multilayer technology used in the drinks bottle industry can be used to create syringes and vials for biologics, avoiding problems such as oxidation and absorption that occur with other materials.
WEARABLES
Ian Thompson
Ypsomed
LARGE-VOLUME PATCH-INJECTION VIA YPSODOSE: SIMPLER FOR PHARMA COMPANIES & PATIENTS
Ian Thompson updates us on the company’s prefilled large-volume patch injector platform, YpsoDose, which simplifies the approach to wearable patch injectors for both pharma companies and patients.
WEARABLES
Sandra De Haan
Sensile Medical
COMPANY SHOWCASE: Sensile Medical
Sensile Medical has achieved a lot since its acquisition by Gerresheimer last year. Here they provide an update on two recent projects: the recent market launch of our first micropump, an infusion pump for Parkinson’s disease patients; and our latest project with SQ Innovation for a 3 mL furosemide patch pump.
WEARABLES
Mindy Katz
Sorrel Medical
A VIAL-BASED SOLUTION FOR WEARABLE DRUG DELIVERY
Mindy Katz and Michael Ratigan describe how, due to the inherent challenges of integrating vials into wearable devices, there has not been a viable, patient-centric option for wearable devices using vials ... until now.
WEARABLES
Victoria Morgan
West Pharmaceutical Services
HOW LARGE-VOLUME WEARABLES REVOLUTIONISE THE PATIENT EXPERIENCE
Victoria Morgan looks at how the combination of large-volume medicines and the trend for wearable devices is transforming life for patients, highlighting the company's new-generation SmartDose 10 mL platform.
WEARABLES
Catherine Thacker
ATS Automation
MITIGATING RISK TO DELIVER SUCCESS IN HIGH-VOLUME WEARABLE DEVICES
Catherine Thacker and Bill Jaworski discuss risk reduction solutions in the manufacturing architecture for wearable injectors, including an example where autonomous intelligent vehicles and ATS‘s real-time industrial IoT manufacturing intelligence system, Illuminate®, were employed.
EXPERT VIEW
Michael Penman
THE CHALLENGES OF VERIFYING A WEARABLE INFUSOR
Michael Penman shows why it is important to verify body-worn infusor performance, highlighting the challenges and learnings from an example where Team Consulting was tasked with the design and verification of one such wearable device.
EXPERT VIEW
Cory Costantino
A QUICK GUIDE TO USABILITY FOR WEARABLE INJECTORS
Cory Costantino and Lauren Fennelly list some typical steps a user might take while using wearable injectors, providing tips and points to note at each step, including design tips that might pre-empt potential interaction problems, and points to consider when conducting usability testing.
CONFERENCE SHOWCASE
Dr Falk Klar
PDA
2019 PDA UNIVERSE OF PRE-FILLED SYRINGES AND INJECTION DEVICES PREVIEW
PDA Europe presents the 16th edition of its signature event Universe of Pre-filled Syringes & Injection Devices – an important conference for people working in the fields of parenteral drug, and device, development, covering solutions to challenges regarding new developments, and regulatory and industry trends.
CONNECTIVITY
Thierry Decock
Nemera
CONNECTED DEVICES – MEDICATION DELIVERY JUST GOT PERSONAL
Thierry Decock and Hadrien Gremillet explore how the obstacles to the adoption of connectivity can be overcome and how connected devices can deliver truly patient-centric care that will clearly improve adherence rates, whilst demonstrating a clear cost benefit to the pharmaceutical partner.
WEARABLES
Jesper Roested
Subcuject
A PATIENT CENTRIC AND PHARMA COMPANY CENTRIC PREFILLED WEARABLE BOLUS INJECTOR
Jesper Roested explains why the pharma/biotech drug development process often means device selection occurs after Phase II despite the advantages of earlier selection being well understood, and how this then precludes the selection of novel primary packaging and delivery systems.
WEARABLES
Victoria Morgan
West Pharmaceutical Services
ALTERING PATIENT TREATMENT: HOW SC DELIVERY CAN HELP PATIENTS MANAGE CHRONIC CONDITIONS
Victoria Morgan looks at the benefits of combining an active pharmaceutical product with a novel subcutaneous delivery device, and highlights some of the partnerships West has with biopharmaceutical and other companies, which have led to market launches of products incorporating its on-body delivery system.
EXPERT VIEW
Jennifer King
PATIENT TOLERABILITY WITH HIGH-VISCOSITY, LARGE-VOLUME SUBCUTANEOUS INFUSIONS
Jennifer King and Matthew J Huddleston discuss the advantages of subcutaneous drug delivery and how these have yet to be fully harnessed in currently marketed therapeutics.
PREFILLED SYRINGES
Dr Eric Chappel
Debiotech
LOW-COST DISPOSABLE WEARABLE INJECTOR PLATFORM FOR LARGE VOLUMES OF VISCOUS DRUGS
Eric Chappel, Dimitry Dumont-Fillon and Laurent-Dominique Piveteau discuss Debiotech’s novel wearable injector technology, which utilises a propellant vapour system to drive the injection, making the device both space- and cost-efficient.
PREFILLED SYRINGES
Mindy Katz
Sorrel Medical
UV STERILISATION & THE CASE FOR PREFILLED & PRELOADED DRUG DELIVERY SYSTEMS
Mindy Katz and Ori Ben-David review the different fill form configurations of drug delivery devices, outlining the importance of the prefilled and preloaded device configuration for self-administering patients.
EXPERT VIEW
Charlotte Harvey
HOW SAFETY FEATURES MAKE OR BREAK INFUSION PUMP DESIGN
Charlotte Harvey and Tim Frearson overview the safety systems required when designing an infusion pump system, with a focus on free-flow prevention, occlusion detection and air-in-line detection.
PREFILLED SYRINGES
Hans Peter Manser
Weibel CDS
LYCAJECT: AUTOMATIC RECONSTITUTION PATCH INJECTOR
Hans Peter Manser, Christoph Egloff and Martin C King introduce the LyCaJect Patch Injector, Weibel CDS’ offering in the field of wearable injectors, with automatic reconstitution as a headline feature.
WEARABLES
Mindy Katz
Sorrel Medical
PREFILLED WEARABLE DRUG DELIVERY: HARNESSING TECHNOLOGY FOR PATIENT & PARTNER CENTRICITY
Mindy Katz describes in detail the company’s journey from identifying a clear market need to development and commercialisation of Sorrel’s prefilled and preloaded wearable injection device.
WEARABLES
Jesper Roested
Subcuject
WEARABLE INJECTORS: THE PERCEPTION OF INHERENT EXPENSE AND COMPLEXITY
There is a widespread belief that wearable injectors are too expensive and complex to really take off as a commercially viable method of drug delivery. Jesper Roested tackles the causes of this belief, and explains why it is not truly the case.
EXPERT VIEW
Paul Jansen
2014 TO 2018: AN UPDATE ON THE STATE OF WEARABLE INJECTORS
Looking back on the developments in large volume injectors since his article in ONdrugDelivery’s 2014 issue on wearable injectors, Paul Jansen reflects on the state of this technology space today, how it has progressed and the value it is likely to offer.
WEARABLES
Dr Jeannie Joughin
Enable Injections
BIOLOGIC DRUGS AND THEIR DELIVERY SYSTEMS: A SYMBIOSIS KEY TO COMMERCIAL SUCCESS
Jeannie Joughin discusses the ever-growing importance of the delivery system in the biologic combination product area, highlighting how it is the delivery system, not the drug, that defines the patient experience.
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