INJECTION

INTERVIEW

Dr Mircea Despa

BD (Becton Dickinson & Company)

MIRCEA DESPA & DOUG McCLURE, BD

In this interview, Dr Despa and Mr McClure discuss BD’s approach to connecting devices in its portfolio to meet patient, pharma and other stakeholder requirements. Their discussion focuses in particular on safety and security, highlighting the connected wearable injector, BD Libertas™ with Smart Option, as an example.

CONNECTIVITY

Matt Jones

DCA

DON’T DEVELOP A CONNECTED DRUG DELIVERY DEVICE WITHOUT READING THIS

Matt Jones summarises some of the key challenges and opportunities in the development of connected drug delivery devices, focusing in detail on deciding what a connected drug delivery device should do, designing for a coin cell, direct cellular connection and antenna design.

EXPERT VIEW

Mark Tunkel

USER-CENTRED DEVICE CONNECTIVITY

Mark Tunkel and Carolyn Rose discuss the benefits of taking a user-needs approach, and mapping the patient journey, in a connectivity strategy.

CONNECTIVITY

Neil Williams

Phillips-Medisize

LOW-COST CONNECTIVITY MEETS PATIENT & PHARMA MEDICATION MANAGEMENT NEEDS

Neil Williams describes the potential connected drug delivery systems hold to address serious challenges in healthcare, including poor adherence, and also deliver substantial value, and outlines the company’s highly scalable enterprise platform, the Connected Health Platform.

CONNECTIVITY

Craig Baker

Noble

ADHERENCE TO SELF-INJECTION REGIMENS CAN BE ENHANCED BY CONNECTED DEVICES

 Craig Baker looks at the factors contributing to non-adherence and explores how connected devices can help patients follow their self-injection regimens.

CONNECTIVITY

Tsachi Shaked

E3D – Elcam Drug Delivery Devices

ADDING CONNECTIVITY TO DRUG DELIVERY DEVICES

Tsachi Shaked explores how – as the trend towards moving healthcare from the hospital to the home continues – connectivity in drug delivery devices may be changing from being the exception to the rule.

WEARABLES

Jesper Roested

Subcuject

A PATIENT CENTRIC AND PHARMA COMPANY CENTRIC PREFILLED WEARABLE BOLUS INJECTOR

Jesper Roested explains why the pharma/biotech drug development process often means device selection occurs after Phase II despite the advantages of earlier selection being well understood, and how this then precludes the selection of novel primary packaging and delivery systems.

INJECTION

Dr Cristianne Rijcken

Cristal Therapeutics

COMPANY SHOWCASE: Cristal Therapeutics

Over the past year, Cristal Therapeutics has transitioned from a research-stage start-up to a fully fledged, clinical-stage business with a promising pipeline of proprietary drug candidates. This diverse pipeline together with the proprietary nanoparticle platform, CriPec^®, presents a broad range of promising late- and early-stage partnering opportunities for companies active in the oncology space.

INJECTION

Dr Elham Blouet

Roquette

A NEW MULTI-COMPENDIA MODIFIED BETA-CYCLODEXTRIN, KLEPTOSE^® HPB-LB PARENTERAL GRADE

Elham Blouet introduces the latest addition to the company’s range of beta-cyclodextrins, and outlines the benefits it brings.

INJECTION

John Merhige

Credence MedSystems

TECHNOLOGY SHOWCASE: Credence MedSystems Multi-Site™ Injection System

Credence MedSystems introduces the Multi-Site™ Injection System – a product that addresses specific needs in the high-growth dermal filler market.

INJECTION

Alfred Harvey

BD (Becton Dickinson & Company)

SELECTING THE RIGHT PRIMARY CONTAINER FOR INJECTABLES IN ACUTE CARE

Alfred Harvey explains why it’s important to select the right primary container presentation – and what can happen if you get it wrong.

WEARABLES

Victoria Morgan

West Pharmaceutical Services

ALTERING PATIENT TREATMENT: HOW SC DELIVERY CAN HELP PATIENTS MANAGE CHRONIC CONDITIONS

Victoria Morgan looks at the benefits of combining an active pharmaceutical product with a novel subcutaneous delivery device, and highlights some of the partnerships West has with biopharmaceutical and other companies, which have led to market launches of products incorporating its on-body delivery system.

INJECTION

Erin Miller

Noble

TRAINING DEVICES INCREASE PATIENT ENGAGEMENT AND ADHERENCE – CREATING BETTER OUTCOMES

Erin Miller outlines a study looking at how patients interact with training resources during the first 14 days of a new treatment – and how training devices can help increase confidence, adherence and, ultimately, overall outcomes for the millions of patients who manage their diseases through self-injection.

INJECTION

Takuya Minezaki

Mitsubishi Gas Chemical

MULTILAYER PLASTIC VIALS & SYRINGES FOR BIOLOGICS

Dr Takuya Minezaki and Tomohiro Suzuki, provide an overview of the company’s OXYCAPT™ Vials and Syringes, explaining how their multi-layered polymer material delivers the advantages of both COP and glass, and is especially suitable for biotherapeutics.

INJECTION

Wolfgang Moersch

ZwickRoell

PRODUCT SHOWCASE: Zwickroell Autoinjector Testing Platform

ZwickRoell introduces RoboTest, its automated autoinjector testing platform, which works together with the AutoEdition 3 automation software ad testXpert III testing software.

EXPERT VIEW

Jennifer King

PATIENT TOLERABILITY WITH HIGH-VISCOSITY, LARGE-VOLUME SUBCUTANEOUS INFUSIONS

Jennifer King and Matthew J Huddleston discuss the advantages of subcutaneous drug delivery and how these have yet to be fully harnessed in currently marketed therapeutics.

INJECTION

Berthold Schopferer

Zahoransky

NEXT-LEVEL FUTURE MANUFACTURING FOR MEDICAL TECHNOLOGY

Berthold Schopferer explains the lengths the production equipment company goes to in its efforts to ensure the customer is always king.

INJECTION

Elektrofi

ENABLING SUBCUTANEOUS DELIVERY OF BIOLOGICS

Elektrofi introduces Elektroject™, a gentle process for the production of ultra-high concentration protein formulations, that maintains a syringeable format and excellent protein stability, making the switch from intravenous to subcutaneous delivery viable for numerous biotherapeutics, including monoclonal antibodies.

INJECTION

Bjarne Sørensen

Phillips-Medisize

A RE-USABLE CONNECTED AUTOINJECTOR CUSTOMISED FOR THE COMPANION^® SAFETY SYRINGE SYSTEM

Bjarne Sørensen and John A. Merhige explore the latest developments in modular autoinjector platforms and the benefits for end users and pharmaceutical customers. They also discuss the two companies’ recent partnership for the development of a combined system that capitalises on important synergies between two compatible technologies.

PREFILLED SYRINGES

SHL Group

SOLUTIONS FOR HIGH-VOLUME DRUG DELIVERY

SHL Group introduces the high-volume variation of its Molly^® family of products, the Molly^® 2.25, and discusses more broadly the advantages that the Molly^® business model offers to pharmaceutical and biotech clients.

PREFILLED SYRINGES

Ingo Stephan

teamtechnik

TECHNOLOGY SHOWCASE: teamtechnik’s LED Cannula Gluing Process

Ingo Stephan introduces a new gluing process for attaching cannulas using LEDs from teamtechnik.

PREFILLED SYRINGES

Justin Schroeder

PCI Pharma Services

BIOLOGIC MEDICINES AND PATIENT-CENTRICITY – A NEW PHASE OF HOPE

Justin Schroeder discusses how the increasing biologics and biosimilars market has driven innovation and a trend towards self-administration and user-centricity in the injectable drug delivery device market.

INTERVIEW

Sagar Bejalwar

BD (Becton Dickinson & Company)

SAGAR BEJALWAR, BD MEDICAL – PHARMACEUTICAL SYSTEMS

Sagar Bejalwar discusses the product and clinician needs in delivering hyaluronic acid for cosmetic applications.

EXPERT VIEW

Marino Kriheli

HAZARDOUS DRUG HANDLING AND INVESTIGATIONAL DRUGS: LESSONS TO LEARN

Marino Kriheli discusses the need for closed-system transfer devices when handling hazardous drugs, particularly as they relate to investigational drugs, not only as key to patient and healthcare practitioner safety, but also in the context of upcoming US regulation.

PREFILLED SYRINGES

Dr Eric Chappel

Debiotech

LOW-COST DISPOSABLE WEARABLE INJECTOR PLATFORM FOR LARGE VOLUMES OF VISCOUS DRUGS

Eric Chappel, Dimitry Dumont-Fillon and Laurent-Dominique Piveteau discuss Debiotech’s novel wearable injector technology, which utilises a propellant vapour system to drive the injection, making the device both space- and cost-efficient.

EXPERT VIEW

Stuart Curtis

SIX TECHNIQUES FOR RAPID EARLY-STAGE MEDICAL DEVICE DEVELOPMENT

Stuart Curtis runs through six techniques which, in his experience, are invaluable for accelerating the early development stages of drug delivery device design and can therefore be of great use when trying to accelerate a product’s time to market.

PREFILLED SYRINGES

Hideaki Kiminami

Terumo Pharmaceutical Solutions

DEVELOPMENT OF PREFILLABLE SYRINGES TO MITIGATE THE RISK OF PARTICLE FORMATION IN BIOPHARMACEUTICALS

Hideaki Kiminami and Philippe Lauwers discuss the problem of particle formation in biopharmaceuticals packaged in prefilled syringes.

PREFILLED SYRINGES

Shota Arakawa

Mitsubishi Gas Chemical

MULTILAYER PLASTIC VIALS & SYRINGES FOR BIOLOGICS

Shota Arakawa and Tomohiro Suzuki discuss OXYCAPT™ Plastic Vial and Syringe, which provides a product with all the advantages of plastic, coupled with strong oxygen and UV barrier properties.

PREFILLED SYRINGES

Mindy Katz

Sorrel Medical

UV STERILISATION & THE CASE FOR PREFILLED & PRELOADED DRUG DELIVERY SYSTEMS

Mindy Katz and Ori Ben-David review the different fill form configurations of drug delivery devices, outlining the importance of the prefilled and preloaded device configuration for self-administering patients.

EXPERT VIEW

Lior Shtram

THE ROAD TO PREFILLED DEVICES IN NOVEL COMBINATION PRODUCTS

Lior Shtram discusses three approaches to delivering novel combination products – user-filled, user-loaded and prefilled – through the lens of sterilisation processes and requirements at the industrial manufacturing scale.

PREFILLED SYRINGES

Josh Hopkins

Noble

IMPROVING PATIENTS’ SELF-INJECTION EXPERIENCE

Jeff Lettman and Josh Hopkins explain how they worked with a client to develop a product that would function with the pre-existing drug delivery device to help rheumatoid arthritis patients with reduced dexterity.

PREFILLED SYRINGES

Janice Adkins

BD (Becton Dickinson & Company)

DRUG-DEVICE CO-PACKING SOLUTIONS TO ENHANCE DIFFERENTIATION AND IMPROVE EXPERIENCE

Janice Adkins discusses the benefits that co-packing, the practice of providing drug preparation and delivery systems along with a medication, can bring to pharmaceutical manufacturers, clinicians and patients.

EXPERT VIEW

Ursula Hahn

SAFE, CONVENIENT AND EFFICIENT: INDIVIDUALISING PREFILLED SYRINGES

Ursula Hahn discusses the value of individualised prefilled syringes and explains how small changes in design or components can make a huge difference for doctors, patients and pharmaceutical manufacturers alike.

EXPERT VIEW

Charlotte Harvey

HOW SAFETY FEATURES MAKE OR BREAK INFUSION PUMP DESIGN

Charlotte Harvey and Tim Frearson overview the safety systems required when designing an infusion pump system, with a focus on free-flow prevention, occlusion detection and air-in-line detection.

INTERVIEW

Dr Alice Maden

BD (Becton Dickinson & Company)

ALICE MADEN & LIONEL MARITAN, BD MEDICAL – PHARMACEUTICAL SYSTEMS

Alice Maden and Lionel Maritan discuss with detailed expert knowledge the benefits of using integrated systems for sophisticated drug device combination products with multiple device subsystems.

PREFILLED SYRINGES

Hans Peter Manser

Weibel CDS

LYCAJECT: AUTOMATIC RECONSTITUTION PATCH INJECTOR

Hans Peter Manser, Christoph Egloff and Martin C King introduce the LyCaJect Patch Injector, Weibel CDS’ offering in the field of wearable injectors, with automatic reconstitution as a headline feature.