PULMONARY

PULMONARY

Inga Meyer

Nemera

INHALIA^®: A NEW pMDI METERING VALVE PLATFORM THAT PATIENTS CAN COUNT ON

Inga Meyer introduces the company’s new pressurised metered-dose inhaler (pMDI) valve platform, Inhalia, and uses device testing study data to demonstrate some of the significant advances, advantages and benefits the platform brings.

PULMONARY

Paul Sullivan

Noble

PATIENT PREFERENCE IN RESPIRATORY DEVICE TRAINING & EDUCATIONAL TOOLS

Paul Sullivan and Craig Baker provide data from recent patient studies to emphasise the importance of training devices in improving adherence to, and compliance with, inhaled therapeutics.

EXPERT VIEW

Mark Tunkel

WHY SUCCESS IN DRUG DELIVERY IS NOT JUST ABOUT THE DEVICE

Mark Tunkel explains how companies developing and marketing inhalable pharmaceuticals can explore other strategies to improve patient outcomes over and above what the drug and device can achieve.

PULMONARY

Dr David Lewis

Chiesi

REVIEWING CURRENT THINKING ON THE IN VIVO BEHAVIOUR OF PARTICLES IN THE EXTRA-FINE REGION

David Lewis reports the latest research on the changing view of the behaviour of particles in the extra-fine region and their potential for enhancing inhaled drug therapies.

PULMONARY

Richard Turner

H&T Presspart

IMPROVING DRUG STABILITY & DRUG DELIVERY BY MODIFICATION OF MDI CANISTER SURFACES

Richard Turner explains how, in recent years, a number of surface coatings have been developed that can be applied to MDIs canisters and valve components, to protect the contents from deposition and degradation.

PULMONARY

Adam Smith

Copley Scientific

A NEW, ADVANCED HIGH-THROUGHPUT SYSTEM FOR AUTOMATED INHALER TESTING

Adam Smith introduces DecaVertus, describing its single inhaler predecessor the Vertus, and how the DecaVertus design evolved using the Vertus technology.

PULMONARY

Dr Paul Kippax

Malvern Panalytical

INVESTIGATING THE DE-AGGLOMERATION PROFILES OF DPI FORMULATIONS

Paul Kippax from Malvern Instruments, Srinivas Ravindra Babu Behara, David Morton, Ian Larson and Peter Stewart from Monash University describe the use of laser diffraction to analyse dry powder behaviour.

PULMONARY

Dr Tim Noakes

Mexichem Fluor

MDI PROPELLANTS – IS THE POPULARITY OF HFA 227EA SET TO GROW?

Tim Noakes predicts a rise in demand for HFA 227ea – a less common MDI propellant than the better-known HFA 134a.

PULMONARY

Mark Copley

Copley Scientific

IMPROVING THE REALISM AND RELEVANCE OF MOUTH-THROAT MODELS FOR INHALED PRODUCT TESTING

Mark Copley provides some background on mouth-throat models for OIP testing.

PULMONARY

David Harris

Team Consulting

THE ADVANTAGES OF DESIGNING HIGH-RESISTANCE SWIRL CHAMBERS

David Harris taps into a powerful combination of detailed anatomical and functional understanding of the human respiratory system, pulmonary drug delivery technology and formulation expertise.

PULMONARY

Dr Anna Fureby

RISE

PULMONARY DELIVERY OF ANTIMICROBIAL PEPTIDES

Anna Fureby, Ulla Elofsson and Per Gerde discuss the serious problem of antibiotic resistance and the potential role of antimicrobial peptides in the treatment of resistant bacterial strains.

PULMONARY

3M Drug Delivery Systems

EXPERTISE IN DEVELOPMENT, MANUFACTURING & COMMERCIALISATION

3M Drug Delivery Systems reports on how it has achieved significant successes thanks to its deep expertise in the field of MDIs.

PULMONARY

Richard Molin

Specialty Coating Systems

PROTECTING INHALATION DRUG DELIVERY DEVICES WITH PARYLENE CONFORMAL COATINGS

Dick Molin describes applications of Parylene coatings as protective barrier coatings in inhalable drug delivery devices, and the detailed characteristics of Parylene which make it particularly suited to these applications.

PULMONARY

Dr Carole Evans

Catalent

QUALITY BY DESIGN IN INHALATION PRODUCT DEVELOPMENT

Carole Evans and Lei Mao explore the application and principles of quality by design in the development, manufacture and commercialisation of inhaled pharmaceutical products.

PULMONARY

Dr Eunice Costa

Hovione

DESIGN OF COMPOSITE PARTICLES VIA SPRAY DRYING FOR DPI FORMULATIONS

Eunice Costa, Filipe Neves and Cláudia Moura describe how composite formulations - API embedded in an excipient matrix - overcome the challenges in inhalation powder development.

PULMONARY

Dr Joel Bell

RTP Company

EFFECTS OF STATIC ON PLASTICS USED IN DRUG DELIVERY DEVICES

Drug delivery in dry-powder and aerosol inhalers can be hindered by static attraction of the drug substance to plastics used in the drug flow path. JoelBell and Josh Blackmore report a series of projects to characterise this interaction.

EXPERT VIEW

Prof David Price

THE SIGNIFICANCE OF INHALER TECHNIQUE & HOW TO IMPROVE IT

Professor David Price describes a significant and long-standing unmet need for inhaler technique to be improved in patients with asthma and COPD, and sets forth strategies to achieve the sorely needed improvements.

PULMONARY

Bert Dekens

Hosokawa Micron

FORMULATION METHODS & SIZE REDUCTION FOR INHALERS

Bert Dekens highlights the importance of achieving the correct particle sizes, both for the API and the carrier in formulations for inhalation, and describes some of the available equipment most suited to specific tasks.

PULMONARY

Thomas Gallem

PARI

THE eFLOW “CLOSED SYSTEM”

Thomas Gallem describes the design and development stages, including the incorporation of human-factors engineering and optimisation for elderly patients, of the company’s eFlow CS nebuliser, which uses a proprietary single-dose drug ampoule as an integral part of the nebuliser handset.

PULMONARY

Badre Hammond

Next Breath

GENERIC PMDI PRODUCT DEVELOPMENT FOR THE US: KEY CONSIDERATIONS

Badre Hammond highlights key considerations and addresses strategies that are believed to reduce risk and ultimately speed up the process for getting a generic pMDI product to the US market.

PULMONARY

Prof Marc Brown

MedPharm

ARTIFICIAL NEURAL NETWORKS & TISSUE MODELS

Marc Brown, Jo Muddle and Professor Clive Page describe the use of artificial neural networks and novel tissue models as methods for formulation candidate screening, selection and characterisation and, in generic product development, for bioequivalence testing.

PULMONARY

Dr Eunice Costa

Hovione

SCALE-UP & QBD APPROACHES FOR SPRAY-DRIED INHALATION FORMULATIONS

Eunice Costa, Filipe Neves, Gonçalo Andrade and Conrad Winters describe the strong position of inhalable products in preclinical and clinical pipelines and make the case for formulation-based approaches to enable and enhance pulmonary product development. Spray-drying technology in particular is highlighted as a highly favourable, scalable manufacturing technique for inhalable composite particles.

CONFERENCE REVIEW

RESPIRATORY DRUG DELIVERY (RDD) 2014

Respiratory Drug Delivery^® celebrated its 25th Anniversary at the El Conquistador Resort in Fajardo, Puerto Rico, from May 4 to May 8, 2014.