PULMONARY

EXPERT VIEW

Mary Hutchens

THE NEW EU MEDICAL DEVICE REGULATIONS – IMPLICATIONS FOR INHALATION DEVICES

Mary Hutchens gives an overview of some of the changes wrought by last year’s introduction of the new EU Medical Device Regulation, with a specific view to its effect on inhalation devices and inhaled medical products.

EXPERT VIEW

Jamie Clayton

CHOOSING THE RIGHT DOSATOR FOR DPI DOSING

Jamie Clayton, Rajeev Dattani and Dave Seaward discuss the operation of dosators for reliable and accurate filling of DPI capsules and blisters.

EXPERT VIEW

Mark Knowles

MEETING FUTURE NEEDS FOR RESPIRATORY DRUG DELIVERY DEVELOPMENT

Mark Knowles and Collette Johnson explore the different elements that need to be considered when developing a smart inhalation drug delivery device to ensure that maximum benefit is obtained.

PULMONARY

Fernando Díez

ACG

THE SCIENCE BEHIND CAPSULE-BASED DRY POWDER INHALATION TECHNOLOGY

Here, Fernando Díez, Justin Kalafat, and Jnanadeva Bhat explain the mechanics behind cDPIs, from the scientific perspective, before looking to the future of cDPIs in the market.

EXPERT VIEW

Ryan Noble

THE LATEST DIGITAL TOOLS REVEAL ACTUAL PATIENT BEHAVIOUR

Ryan Noble and Tom Lawrie-Fussey discuss the potential of digital innovations to improve understanding of real patient behaviour and consequently increase adherence.

PULMONARY

Dr Anselm Ebert

H&T Presspart

A SIMPLE AFFORDABLE DPI: MEETING THE NEEDS OF EMERGING MARKETS

Anselm Ebert, João Ventura Fernandes, Ameet Sule and Sunita Sule discuss the rising need for respiratory medication in the developing world. They go on to highlight the novel challenges presented by these new markets and explain how a new DPI, PowdAir Plus™, meets those challenges, offering a solution to the increase in chronic respiratory conditions across the globe.

PULMONARY

Brian E Jones

Qualicaps

AN OVERVIEW OF DRY POWDER INHALATION FOR SYSTEMIC DRUG DELIVERY

Brian Jones and Susana Ecenarro Probst discuss the growing interest in using inhaled APIs to treat systemic conditions. Furthermore, they review some of the methods used to engineer molecules to be suitable for DPI capsules and look to the possibility of administering biomolecules via the pulmonary route.

PULMONARY

Joe Reynolds

Noble

DEVELOPING EFFECTIVE TRAINING DEVICES FOR THE PULMONARY HEALTHCARE MARKET

Pulmonary drug delivery is an effective route of pharmaceutical administration but research has shown that a large majority of patients fail to use their devices properly, training devices can help address this problem. Joe Reynolds looks at the design challenges that need to be addressed as well as some of the latest features that can be incorporated to develop optimal training devices for patients.

PULMONARY

Simon Strothers

3P Innovation

A NOVEL POWDER FILLING TECHNOLOGY TO REDUCE DEVELOPMENT COSTS & TIMELINES

Simon Strothers and Dave Seaward discuss the evolution of filling technology in the inhaled world, including a new technology and approach to filling which offers significant advantages over conventional filling systems.

EXPERT VIEW

Dr Simon Moore

KEY CONSIDERATIONS FOR NON-CLINICAL SAFETY ASSESSMENT OF INHALED BIOPHARMACEUTICALS

Simon Moore, Kirsty Haprer and Sylwia Marshall highlight some of the key considerations for the development of inhaled biopharmaceuticals, including non-clinical safety assessment.

PULMONARY

Proveris Scientific

WHAT IS QUALITY BY DESIGN AND WHY SHOULD YOU CARE?

Proveris Scientific explains quality by design (QbD), a scientific approach that formalises product design, automates manual testing, and streamlines troubleshooting.

PULMONARY

Bergdis Sigurdardottir

Baumann

THE IMPORTANCE OF SPRING AND STAMPING QUALITY IN INHALER SAFETY

Frank Reiss and Bergdis Sigurdardottir explain how medical competence in spring and stamping manufacturing may prove critical for the developers of inhalers.

INTERVIEW

Dimitri Grasswill

Nemera

DIMITRI GRASSWILL, NEMERA

Dimitri Grasswill speaks with ONdrugDelivery Magazine, in the context of the changing market and technology around inhalation devices.

PULMONARY

Joe Reynolds

Noble

TRAINING DEVICE OPPORTUNITIES

Joe Reynolds outlines the increasing range of options available for helping patients learn how to use their devices correctly and maximise the effectiveness of their treatments.

PULMONARY

Aptar Pharma

PRODUCT SHOWCASE: APTAR PHARMA’S MDI eDOSE COUNTER

Aptar Pharma, will unveil its latest innovation, the eDose Counter for metered dose inhalers (MDIs), at the RDD Europe scientific conference in Antibes, France, on April 25-28, 2017.

PULMONARY

Inga Meyer

H&T Presspart

DOSE COUNTERS & INDICATORS – MEETING A REAL PATIENT NEED

Inga Meyerand Kyle Wilson explain how their dose counter-enabled inhaler development work has led to the production of a system that accurately indicates the end of life of a device.

INTERVIEW

Bill Welch

Phillips-Medisize

BILL WELCH, PHILIPS-MEDISIZE

Mr Welch gives ONdrugDelivery Magazine an exclusive preview of Phillips-Medisize’s forthcoming workshop, “Realizing the Benefits of Connected Health in Respiratory Drug Delivery”.

PULMONARY

Dr Filipa Maia

Hovione

INTEGRATED DESIGN SPACE TO DEVELOP BETTER DPI FORMULATIONS

Filipa Maia and Maria Palha report a study whose objective was to establish relationships between blend rheology, product performance and capsule filling process efficiency.

CONFERENCE SHOWCASE

Dr Philip Kuehl

ISAM - International Society of Aerosols in Medicine

THE 21ST INTERNATIONAL SOCIETY FOR AEROSOLS IN MEDICINE CONGRESS

The International Society for Aerosols in Medicine (ISAM) is a scientific society focused on all areas of aerosols including health effects of aerosols and pulmonary drug delivery.

EXPERT VIEW

Stephen Duckworth

ASSURE INHALER SAFETY & PERFORMANCE: POLYMERS, COLOUR & ADDITIVES

Stephen J Duckworth describes some of the application of polymer colourants and additives in respiratory drug delivery devices, highlighting the strict regulatory environment.

PULMONARY

Jean Vuillecard

Biocorp

PRODUCT SHOWCASE: BIOCORP’S INSPAIR^™

Inspair™ is a sensing technology able to measure inhalation metrics and therefore provide an accurate insight into actual doses consumed.

EXPERT VIEW

Harry Peters

SELECTION OF EXCIPIENTS FOR DRY POWDER INHALERS

Harry Peters and Gerald Hebbink explain how, because dry powder inhalers need a carrier to help with ensuring the drug is effectively delivered, interest has been focused on developing inhalation-grade lactose for this purpose.

PULMONARY

Jean Vuillecard

Biocorp

LEVERAGE TECH TO OVERCOME PULMONARY DELIVERY BARRIERS

Jean Vuillecard and Eric Dessertenne define the limitations of traditional strategies to train, educate and track adherence with inhaled therapeutics and show how connectivity and other add-on digital tech can support these strategies healthcare providers require.

PULMONARY

Paul Sullivan

Noble

PATIENT PREFERENCE: DEVICE TRAINING & EDUCATION TOOLS

Paul Sullivan and Craig Baker point out that most patients with asthma do not use their inhaler properly, and review evidence from a trial of five different methods designed to improve inhaler use. They conclude that training devices could be effective tools to increase patient confidence and reduce anxiety.

PULMONARY

Susana Ecenarro Probst

Qualicaps

AN ENVIRONMENTALLY FRIENDLY & EFFICIENT DOSAGE FORM

Susana Ecenarro Probst presents evidence, set against the backdrop of environmental concerns over HFC propellants in MDIs, supporting the adoption of dry-powder inhalers as an attractive alternative.

EXPERT VIEW

David Harris

LEARNING TO WALK BEFORE WE RUN

David Harris highlights basic problems with inhalers that persist today, and describes why - as the industry looks increasingly towards developing "smart" and connected inhalers - it is important to remember to solve these basic problems.

PULMONARY

Dr João Ventura Fernandes

Hovione Technology Ltd

SCALING-UP FOR HIGH DOSE DELIVERY TO THE LUNGS

João Ventura Fernandes, Gonçalo Rebelo de Andrade and Peter Villax describe the scaling up of the currently marketed TwinCaps® inhaler into the new TwinMax™ design for high-dose delivery of challenging drug-alone formulations in single to short-term treatments and emergency situations.

PULMONARY

Déborah Le Pennec

Malvern Panalytical

GENERIC NEBULISER BIOEQUIVALENCE: OPTIMISING ANALYTICAL STRATEGIES

Déborah Le Pennec, Laurent Vecellio, Paul Kippax and Stephane Rouquette look at the optimal application of laser diffraction and automated imaging within the context of the US FDA guidance for the in vitro demonstration of bioequivalence in a generic nebuliser.

EXPERT VIEW

Stephen Duckworth

ADDING COLOUR & FUNCTIONALITY TO PLASTICS USED IN MEDICAL DEVICES

Stephen Duckworth explains how – with an emphasis on the importance of complying with stringent and changing pharmaceutical regulations – advanced additives in plastics used to make drug delivery devices can significantly enhance the product.

PULMONARY

Alan Tweedie

Chiesi

ENHANCING THE PERFORMANCE OF DRY POWDER INHALERS: BREATH ACTUATED MECHANISMS

David Lewis and Alan Tweedie explain how BAMs work and present experimental data demonstrating their ability to control dose delivery.

PULMONARY

Noble

COMPANY SHOWCASE: NOBLE

Noble®, the leader in onboarding and device training, is a full-service, patient-centred product development and manufacturing company.

PULMONARY

Bill Welch

Phillips-Medisize

SYSTEMS ENGINEERING FOR COMPLEX PORTABLE DRUG DELIVERY DEVICE DEVELOPMENT

Bill Welch explains how a systems-engineering approach provides an efficient method of developing smaller, smarter and more complex inhaler devices.

PULMONARY

Adam Smith

Copley Scientific

COMPANY SHOWCASE: NOVI

In December 2015 the inhaler automation specialists Novi Systems launched their latest product, a ten-way shake and fire system for pMDIs called DecaVertus. Novi continues to innovate, bringing efficiency, precision and repeatability to inhalation labs around the world.

PULMONARY

Vaishali Kamat

Cambridge Consultants

IT’S JUST AN APP, ISN’T IT?

Vaishali Kamat and Jaquie Finn, outline some key questions that pharma companies should ask before embarking on the development of a connected health solution, and provide insights that could help companies make the most from their investment.

PULMONARY

Dr David L Hava

Pulmatrix

ADVANCES IN PULMONARY DELIVERY OF INHALED ANTI-INFECTIVES

With the growing problems caused by antimicrobial resistance, there is increasing interest in the use of improved strategies for drug delivery. David L. Hava explores the benefits of nebulised inhaled antibiotics delivered via high throughput nebulisers for aqueous formulations or dry powder inhalations for cystic fibrosis patients.

PULMONARY

Dr Gabriela Dujovny

Qualicaps

OPTIMAL SOLUTION FOR DIFFERENT INSPIRATIONAL RATES

There is a wide range of devices available to deliver inhalation therapies, but there is increasing interest in the use of dry powder inhalers due to improved engineering and powder formulations. Gabriela Dujovny looks at the advantages and disadvantages of the DPIs currently available.