RESPIRATORY

PULMONARY

Simon Strothers

3P Innovation

A NOVEL POWDER FILLING TECHNOLOGY TO REDUCE DEVELOPMENT COSTS & TIMELINES

Simon Strothers and Dave Seaward discuss the evolution of filling technology in the inhaled world, including a new technology and approach to filling which offers significant advantages over conventional filling systems.

EXPERT VIEW

Dr Simon Moore

KEY CONSIDERATIONS FOR NON-CLINICAL SAFETY ASSESSMENT OF INHALED BIOPHARMACEUTICALS

Simon Moore, Kirsty Haprer and Sylwia Marshall highlight some of the key considerations for the development of inhaled biopharmaceuticals, including non-clinical safety assessment.

CONNECTIVITY

Conor Mulcahy

Jabil Healthcare

SMART DRUG DELIVERY: PRAGMATIC APPROACH REDUCES RISK, INCREASES INNOVATION & PATIENT ADHERENCE

Getting patients to adhere to long-term therapy for asthma and chronic obstructive pulmonary disease remains a difficult issue to tackle. Conor Mulcahy discusses a smart inhaler which could help solve this problem.

CONNECTIVITY

Dr Benjamin Jung

H&T Presspart

EMBEDDED CONNECTED METERED DOSE INHALERS MEETING REQUIREMENTS FOR MASS ADOPTION

Benjamin Jung and Dana Shears describe the role connected devices can play in the treatment of asthma and COPD, discuss the requirements for mass adoption, and introduce H&T Presspart's inhaler, the eMDI, which has connectivity fully embedded.

EXPERT VIEW

Garth Sutherland

THE POTENTIAL OF CONNECTED DEVICES FOR TACKLING ASTHMA

Garth Sutherland and Jon-Paul Sherlock explain how a strategic partnership between pharmaceutical companies and digital health companies can achieve improved outcomes through joint initiatives.

PULMONARY

Proveris Scientific

WHAT IS QUALITY BY DESIGN AND WHY SHOULD YOU CARE?

Proveris Scientific explains quality by design (QbD), a scientific approach that formalises product design, automates manual testing, and streamlines troubleshooting.

PULMONARY

Bergdis Sigurdardottir

Baumann

THE IMPORTANCE OF SPRING AND STAMPING QUALITY IN INHALER SAFETY

Frank Reiss and Bergdis Sigurdardottir explain how medical competence in spring and stamping manufacturing may prove critical for the developers of inhalers.

EXPERT VIEW

Dr Karlheinz Seyfang

INNOVATIVE NASAL APPLICATION REQUIRES INNOVATIVE FILLING TECHNOLOGY

Karlheinz Seyfang discusses the development of a system for the nasal delivery of a thixotropic gel formulation, from the design of the system through to the production line.

PULMONARY

Joe Reynolds

Noble

TRAINING DEVICE OPPORTUNITIES

Joe Reynolds outlines the increasing range of options available for helping patients learn how to use their devices correctly and maximise the effectiveness of their treatments.

INTERVIEW

Dimitri Grasswill

Nemera

DIMITRI GRASSWILL, NEMERA

Dimitri Grasswill speaks with ONdrugDelivery Magazine, in the context of the changing market and technology around inhalation devices.

PULMONARY

Aptar Pharma

PRODUCT SHOWCASE: APTAR PHARMA’S MDI eDOSE COUNTER

Aptar Pharma, will unveil its latest innovation, the eDose Counter for metered dose inhalers (MDIs), at the RDD Europe scientific conference in Antibes, France, on April 25-28, 2017.

PULMONARY

Inga Meyer

H&T Presspart

DOSE COUNTERS & INDICATORS – MEETING A REAL PATIENT NEED

Inga Meyerand Kyle Wilson explain how their dose counter-enabled inhaler development work has led to the production of a system that accurately indicates the end of life of a device.

EXPERT VIEW

Dr S Mohan Mohanraj

CONTROLLED-RELEASE SYSTEMS FOR PROTEINS & PEPTIDES

S Mohan Mohanraj and Meier Kende discuss development of a viable intranasal microsphere-based delivery system and how it delivers a recombinant anthrax vaccine via two-dose immunisation.

INTERVIEW

Bill Welch

Phillips-Medisize

BILL WELCH, PHILIPS-MEDISIZE

Mr Welch gives ONdrugDelivery Magazine an exclusive preview of Phillips-Medisize’s forthcoming workshop, “Realizing the Benefits of Connected Health in Respiratory Drug Delivery”.

PULMONARY

Dr Filipa Maia

Hovione

INTEGRATED DESIGN SPACE TO DEVELOP BETTER DPI FORMULATIONS

Filipa Maia and Maria Palha report a study whose objective was to establish relationships between blend rheology, product performance and capsule filling process efficiency.

CONFERENCE SHOWCASE

Dr Philip Kuehl

ISAM - International Society of Aerosols in Medicine

THE 21ST INTERNATIONAL SOCIETY FOR AEROSOLS IN MEDICINE CONGRESS

The International Society for Aerosols in Medicine (ISAM) is a scientific society focused on all areas of aerosols including health effects of aerosols and pulmonary drug delivery.

EXPERT VIEW

Stephen Duckworth

ASSURE INHALER SAFETY & PERFORMANCE: POLYMERS, COLOUR & ADDITIVES

Stephen J Duckworth describes some of the application of polymer colourants and additives in respiratory drug delivery devices, highlighting the strict regulatory environment.

PULMONARY

Jean Vuillecard

Biocorp

PRODUCT SHOWCASE: BIOCORP’S INSPAIR^™

Inspair™ is a sensing technology able to measure inhalation metrics and therefore provide an accurate insight into actual doses consumed.

EXPERT VIEW

Harry Peters

SELECTION OF EXCIPIENTS FOR DRY POWDER INHALERS

Harry Peters and Gerald Hebbink explain how, because dry powder inhalers need a carrier to help with ensuring the drug is effectively delivered, interest has been focused on developing inhalation-grade lactose for this purpose.

PULMONARY

Jean Vuillecard

Biocorp

LEVERAGE TECH TO OVERCOME PULMONARY DELIVERY BARRIERS

Jean Vuillecard and Eric Dessertenne define the limitations of traditional strategies to train, educate and track adherence with inhaled therapeutics and show how connectivity and other add-on digital tech can support these strategies healthcare providers require.

PULMONARY

Paul Sullivan

Noble

PATIENT PREFERENCE: DEVICE TRAINING & EDUCATION TOOLS

Paul Sullivan and Craig Baker point out that most patients with asthma do not use their inhaler properly, and review evidence from a trial of five different methods designed to improve inhaler use. They conclude that training devices could be effective tools to increase patient confidence and reduce anxiety.

PULMONARY

Susana Ecenarro Probst

Qualicaps

AN ENVIRONMENTALLY FRIENDLY & EFFICIENT DOSAGE FORM

Susana Ecenarro Probst presents evidence, set against the backdrop of environmental concerns over HFC propellants in MDIs, supporting the adoption of dry-powder inhalers as an attractive alternative.

EXPERT VIEW

David Harris

LEARNING TO WALK BEFORE WE RUN

David Harris highlights basic problems with inhalers that persist today, and describes why - as the industry looks increasingly towards developing "smart" and connected inhalers - it is important to remember to solve these basic problems.

PULMONARY

Dr João Ventura Fernandes

Hovione Technology Ltd

SCALING-UP FOR HIGH DOSE DELIVERY TO THE LUNGS

João Ventura Fernandes, Gonçalo Rebelo de Andrade and Peter Villax describe the scaling up of the currently marketed TwinCaps® inhaler into the new TwinMax™ design for high-dose delivery of challenging drug-alone formulations in single to short-term treatments and emergency situations.

PULMONARY

Déborah Le Pennec

Malvern Panalytical

GENERIC NEBULISER BIOEQUIVALENCE: OPTIMISING ANALYTICAL STRATEGIES

Déborah Le Pennec, Laurent Vecellio, Paul Kippax and Stephane Rouquette look at the optimal application of laser diffraction and automated imaging within the context of the US FDA guidance for the in vitro demonstration of bioequivalence in a generic nebuliser.

NASAL

Pascale Farjas

Nemera

A TRUE PLATFORM OFFERING EFFICIENT NASAL DOSE DELIVERY

Millions of people suffering from allergic rhinitis use nasal sprays manufactured by Nemera every day. Pascale Farjas, provides an overview of an innovative nasal delivery system, Advancia®, a true platform.

EXPERT VIEW

Stephen Duckworth

ADDING COLOUR & FUNCTIONALITY TO PLASTICS USED IN MEDICAL DEVICES

Stephen Duckworth explains how – with an emphasis on the importance of complying with stringent and changing pharmaceutical regulations – advanced additives in plastics used to make drug delivery devices can significantly enhance the product.

CONNECTIVITY

Garth Sutherland

Adherium

CONNECTED INHALERS MAKING A REAL IMPACT ON RESPIRATORY OUTCOMES

Garth Sutherland describes the problem of chronic non-adherence in asthma and COPD, how Adherium’s Smartinhaler™ solutions have proved themselves in the clinic, and why now is the time to move to real-world scale.

EXPERT VIEW

Napoleon Monroe

CONNECTED COMBINATION PRODUCTS: PAST, PRESENT & FUTURE

Napoleon Monroe provides an overview of connected health with a focus on drug delivery systems, beginning by showing that connected health has not suddenly emerged out of nowhere but, rather, it has been developing and evolving over many decades, even centuries.

CONNECTIVITY

Eric Dessertenne

Biocorp

THE MULTIPLE VALUES OF INTEGRATED SOLUTIONS

Arnaud Guillet and Eric Dessertenne, both of Biocorp outline the potential value of the data that can be collected from integrated devices, not only for pharma companies but also for patients and payers.

PULMONARY

Alan Tweedie

Chiesi

ENHANCING THE PERFORMANCE OF DRY POWDER INHALERS: BREATH ACTUATED MECHANISMS

David Lewis and Alan Tweedie explain how BAMs work and present experimental data demonstrating their ability to control dose delivery.

RESPIRATORY

Aptar Pharma

PRODUCT SHOWCASE: DF30 WITH COCe: ULTRA-CLEAN, ROBUST & VERSATILE

Aptar Pharma’s new DF30 metering valve version incorporates a cyclic-olefincopolymer (COC) neck gasket to enhance its performance further. It is the result of continuous improvement to today’s worldleading DF30 technology platform.

PULMONARY

Noble

COMPANY SHOWCASE: NOBLE

Noble®, the leader in onboarding and device training, is a full-service, patient-centred product development and manufacturing company.

PULMONARY

Bill Welch

Phillips-Medisize

SYSTEMS ENGINEERING FOR COMPLEX PORTABLE DRUG DELIVERY DEVICE DEVELOPMENT

Bill Welch explains how a systems-engineering approach provides an efficient method of developing smaller, smarter and more complex inhaler devices.

PULMONARY

Adam Smith

Copley Scientific

COMPANY SHOWCASE: NOVI

In December 2015 the inhaler automation specialists Novi Systems launched their latest product, a ten-way shake and fire system for pMDIs called DecaVertus. Novi continues to innovate, bringing efficiency, precision and repeatability to inhalation labs around the world.

PULMONARY

Vaishali Kamat

Cambridge Consultants

IT’S JUST AN APP, ISN’T IT?

Vaishali Kamat and Jaquie Finn, outline some key questions that pharma companies should ask before embarking on the development of a connected health solution, and provide insights that could help companies make the most from their investment.