TRANSDERMAL

SKIN

Cécile Morin

Gattefossé

SYNERGISING EXCIPIENTS TO BOOST SKIN DELIVERY

Cécile Morin and Delphine Marchaud discuss combining polar and apolar excipients in topical formulations in order produce synergies that maximise the performance of the drug.

SKIN

Dr Aparajita Khatri

Ceramisphere Health

SILICA NANO-SOLUTIONS FOR SKIN DELIVERY

Aparajita Khatri and Christophe A Barbé outline the growth of the dermal delivery market, as well as the challenges it faces. The authors go on to detail a nanocomposite lidocaine patch.

SKIN

Prof Marc Brown

MedPharm

COST-EFFECTIVE APPROACHES FOR SUCCESSFUL GENERIC DERMAL DRUG PRODUCT AUTHORISATIONS

Marc Brown, Jon Lenn and Jeremy Dummond discuss various methods and advantages of in vitro bioequivalence studies for topical skin application, and how MedPharm’s unique technologies and experience can be invaluable in the effective development of generics in this field.

EXPERT VIEW

Petra Botzem

QUALITY BY DESIGN IN TDS DEVELOPMENT: BENEFIT OR BUREAUCRATIC BURDEN?

Petra Botzem and Thomas Hille discuss the Quality-by-Design approach to the development of transdermal drug delivery systems as laid out in ICH guideline Q8.

TRANSDERMAL

Megan Greth

ARx

THE CRITICALITY OF ADHESIVE SELECTION FOR OPTIMAL TRANSDERMAL DRUG DELIVERY SYSTEMS

Megan Greth and Gozde Karabiyik discuss why selecting the right adhesive for body-worn drug delivery systems – be they transdermal patches or wearable injection devices or pumps – is critical for a successful outcome.

TRANSDERMAL

Tony Copley

Copley Scientific

OPTIMISING IN VITRO TESTING FOR TRANSDERMAL AND TOPICAL DRUG PRODUCTS

Tony Copley examines the regulatory framework for transdermal and topical products and popular, effective and cost-efficient in vitro testing techniques for quantifying their release characteristics.

TRANSDERMAL

Prof Marc Brown

MedPharm

NEW RESEARCH TOOLS FOR TOPICAL & TRANSDERMAL DEVELOPMENT

Marc Brown, Rob Turner and James Gibbons provide a view on the current topical and transdermal market, elaborate on some of the common approaches to product development in this area, and reveal the company’s newest model, the MedFlux-HT™ system.

TRANSDERMAL

Pierre Michelet

GEKA Healthcare

MICROBRISTLE APPLICATOR (MBA™) SYSTEMS FOR TOPICAL AND TRANSDERMAL DRUG APPLICATION

Pierre Michelet, Karl Hartstock-Martin, and Moritz Beyhl present the innovative technology of microbristle applicators (MBA™) for a more precise and hygienic application within topical and transdermal treatment. MBA™ comprises a platform of moulded, pure plastic applicators with very fine bristles to apply liquid and semi-liquid formulations.

MICRONEEDLES

Dr Lisa A Dick

3M Drug Delivery Systems

MEETING EVOLVING BIOLOGICS & SMALL MOLECULES NEEDS

Lisa A Dick provides a run-down of the concept, design and development of the company’s microneedle drug delivery platform, both hollow and solid needle arrays, including recent clinical trials of the hollow-needle device.

TRANSDERMAL

Prof Marc Brown

MedPharm

AQUARMED™: TRANSDERMAL DELIVERY USING NOVEL COMPONENTS

Marc Brown, Adrian Williams and James Gibbons explain how the company has developed AquaRMed and describe the potential benefits it could offer patients and companies alike.

MICRONEEDLES

Dr Jung Dong Kim

Raphas

Q&A: SUCCESSFUL MASS PRODUCTION OF AN INNOVATIVE DRUG DELIVERY TECHNOLOGY

Jung Dong Kim answers questions about the company, its capabilities, and the mass production of an innovative dissolving microstructure drug delivery technology.

MICRONEEDLES

Dr Marion Sausse Lhernould

Novinject

HIGHLY CUSTOMISABLE HOLLOW POLYMER MICRONEEDLE SOLUTIONS

Marion Sausse Lhernould, Serge Tailler, Michel Deleers and Alain Delchambre present a hollow microneedle delivery device manufactured using a novel proprietary process.

TRANSDERMAL

Dr Alan Smith

4P Therapeutics

NOVEL TRANSDERMAL DELIVERY SYSTEMS FOR TREATMENT OF DIABETES

Alan Smith outlines the stages of Type 2 diabetes treatment, progressing to extenatide and insulin injections, and makes the case, using clinical data, for the transdermal route as a viable alternative to injections.

EXPERT VIEW

Bruce K Redding

TRANSDERMAL DELIVERY DEVICE DESIGN

Bruce K Redding Jnr gives an overview of the different types of transdermal patch design, as well as the various methods of getting through the skin.

EXPERT VIEW

Dr Kevin Pang

TRANSDERMAL DELIVERY AS A NEW SOURCE FOR BIOPHARMA INNOVATION

Kevin Pang discusses the potential of transdermal delivery, how it has thus far failed to live up to it and how a combination of formulation and electronic advancements mean it could soon be realised.

TRANSDERMAL

Bruce K Redding

DESIGNING AN ULTRASOUNDENABLED PATCH FOR INSULIN

Bruce K Redding Jr tells the story of the design and development of the U-Strip™ Insulin Transdermal Delivery System.